Venous thromboembolism during pregnancy and postpartum period: an updated review.

Minerva Med

Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA -

Published: October 2024

AI Article Synopsis

  • - Venous thromboembolism (VTE) significantly contributes to maternal mortality, with pregnant and postpartum women at about five times greater risk than non-pregnant women due to increased clotting tendencies during this period.
  • - Various non-obstetric risk factors can further elevate the likelihood of VTE, making it essential to distinguish symptoms since they may resemble normal pregnancy signs.
  • - Diagnosis relies on tools like D-dimer testing, ultrasonography, and CT pulmonary angiography, while treatment primarily involves anticoagulation with heparin, though advanced therapies are available for high-risk cases.

Article Abstract

Venous thromboembolism (VTE) is a leading cause of maternal mortality. The risk of VTE in pregnant and postpartum women is ~ five times higher compared with non-pregnant women. There is a physiological tendency to a hypercoagulable state, from conception to the postpartum period. Several non-obstetric risk factors independently increase the risk of VTE. Since most signs and symptoms of VTE might mimic those of a normal pregnancy, a high index of suspicion is warranted to establish the diagnosis. D-dimer, ultrasonography and computed tomography pulmonary angiography are the primary tools for VTE diagnosis. Management mainly revolves around systemic anticoagulation with heparin. Advanced therapy options exist, but these can be considered for selected high-risk cases.

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0026-4806.24.09242-5DOI Listing

Publication Analysis

Top Keywords

venous thromboembolism
8
postpartum period
8
risk vte
8
vte
5
thromboembolism pregnancy
4
pregnancy postpartum
4
period updated
4
updated review
4
review venous
4
thromboembolism vte
4

Similar Publications

A new risk assessment model of venous thromboembolism by considering fuzzy population.

BMC Med Inform Decis Mak

December 2024

Department of Respiration, Peking Union Medical College Hospital, No.1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Background: Inpatients with high risk of venous thromboembolism (VTE) usually face serious threats to their health and economic conditions. Many studies using machine learning (ML) models to predict VTE risk overlook the impact of class-imbalance problem due to the low incidence rate of VTE, resulting in inferior and unstable model performance, which hinders their ability to replace the Padua model, a widely used linear weighted model in clinic. Our study aims to develop a new VTE risk assessment model suitable for Chinese medical inpatients.

View Article and Find Full Text PDF

Development and validation of a nomogram for predicting venous thromboembolism risk in post-surgery patients with cervical cancer.

World J Surg Oncol

December 2024

Chongqing Cancer Multiomics Big Data Application Engineering Research Center, Chongqing University Cancer Hospital, Chongqing, 400030, China.

Objective: Postoperative venous thromboembolism (VTE) is a potentially life-threatening complication. This study aimed to develop a predictive model to identify independent risk factors and estimate the likelihood of VTE in patients undergoing surgery for cervical cancer.

Methods: We conducted a retrospective cohort study involving 1,174 patients who underwent surgery for cervical carcinoma between 2019 and 2022.

View Article and Find Full Text PDF

The incidence of venous thromboembolism is low when risk stratification-based thromboprophylaxis is used after fast-track hip and knee arthroplasty.

BMC Musculoskelet Disord

December 2024

Department of Surgery, Hospital Nova of Central Finland, Wellbeing Services County of Central Finland, Jyväskylä, University of Eastern Finland, Kuopio, Finland.

Background: The optimal length of thromboprophylaxis after total hip or knee arthroplasty (THA and TKA) is unknown. Fast-track protocols have improved patient care and led to shorter immobilization and length of stay (LOS) after THA and TKA, thereby diminishing venous thromboembolism (VTE) risk. Here, we investigated risk stratification-based thromboprophylaxis after fast-track THA and TKA.

View Article and Find Full Text PDF

Uncovering novel therapeutic clues for hypercoagulable active ulcerative colitis: novel findings from old data.

Gastroenterol Rep (Oxf)

December 2024

Department of Cardiovascular Surgery, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong, P. R. China.

Background: Hypercoagulability has been shown to act as an important component of ulcerative colitis (UC) pathogenesis and disease activity, and is strongly correlated with the occurrence of venous thromboembolism (VTE). This study aimed at providing novel therapeutic clues for hypercoagulable active UC.

Methods: The coagulation score model was developed using VTE cohorts, and the predictive performance of this model was evaluated by coagulation subtypes of UC patients, which were clustered by the unsupervised method.

View Article and Find Full Text PDF

This 61-minute webcast features a conversation about "Pulmonary Embolism"-the focus of Issue 20.3. Hosted by the issue's editors, the discussion engages the authors on emerging themes and lessons learned while researching and writing the articles.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!