AI Article Synopsis

  • - The study examines the relationship between amyloid beta (Aβ) PET scans and Aβ biomarkers in cerebrospinal fluid (CSF) to assess their effectiveness in treating Aβ-related conditions.
  • - A total of 505 participants aged 50 and older were analyzed, with a focus on their Aβ levels as measured by both PET and CSF, and a subgroup of 47 who underwent autopsy for further validation.
  • - Results indicated that Aβ PET scans detected earlier Aβ accumulation in the brain compared to CSF biomarkers, showing a higher sensitivity for identifying early stages of Aβ deposition.

Article Abstract

Introduction: Understanding the relationship between amyloid beta (Aβ) positron emission tomography (PET) and Aβ cerebrospinal fluid (CSF) biomarkers will define their potential utility in Aβ treatment. Few population-based or neuropathologic comparisons have been reported.

Methods: Participants 50+ years with Aβ PET and Aβ CSF biomarkers (phosphorylated tau [p-tau]181/Aβ42, n = 505, and Aβ42/40, n = 54) were included from the Mayo Clinic Study on Aging. From these participants, an autopsy subgroup was identified (n = 47). The relationships of Aβ PET and Aβ CSF biomarkers were assessed cross-sectionally in all participants and longitudinally in autopsy data.

Results: Cross-sectionally, more participants were Aβ PET+ versus Aβ CSF- than Aβ PET- versus Aβ CSF+ with an incremental effect when using Aβ PET regions selected for early Aβ deposition. The sensitivity for the first detection of Thal phase ≥ 1 in longitudinal data was higher for Aβ PET (89%) than p-tau181/Aβ42 (64%).

Discussion: Aβ PET can detect earlier cortical Aβ deposition than Aβ CSF biomarkers. Aβ PET+ versus Aβ CSF- findings are several-fold greater using regional Aβ PET analyses and in peri-threshold-standardized uptake value ratio participants.

Highlights: Amyloid beta (Aβ) positron emission tomography (PET) has greater sensitivity for Aβ deposition than Aβ cerebrospinal fluid (CSF) in early Aβ development. A population-based sample of participants (n = 505) with PET and CSF tests was used. Cortical regions showing early Aβ on Aβ PET were also used in these analyses. Neuropathology was used to validate detection of Aβ by Aβ PET and Aβ CSF biomarkers.

Download full-text PDF

Source
http://dx.doi.org/10.1002/alz.14317DOI Listing

Publication Analysis

Top Keywords

aβ pet
32
30
csf biomarkers
20
pet aβ
16
aβ csf
16
versus aβ
12
early aβ
12
aβ deposition
12
pet
11
csf
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!