AI Article Synopsis
- The corneal epithelium is vital for nutrient absorption and distribution on the eye's surface, relying on numerous nerve endings.
- Various studies have examined different methods to boost tear production and manage corneal disorders, emphasizing the importance of enhancing corneal nerve function through techniques like neurostimulation and medication.
- This review aims to summarize current research on improving corneal nerve function and overall eye health by focusing on modifying the trigeminal pathway, with an emphasis on finding new treatment strategies for corneal degeneration.
Article Abstract
The corneal epithelium, supplied by thousands of nerve endings, plays a substantial role in absorbing and distributing nutrients along the ocular surface. Many studies have explored the influence of various modalities in regulating tear production to manage corneal disorders and dry eye disease. These findings have highlighted the advantages of enhancing corneal nerve function and regeneration through neurostimulation, neural signaling, immunomodulation, topical medication application, and surgical reconstruction. The purpose of this narrative review article was to provide an overview of the current state of knowledge on this topic based on a PubMed database literature search for relevant animal and human studies investigating the modification of the trigeminal pathway to restore corneal nerve function and improve overall ocular health. Further investigation into this area of research is important to help guide new therapeutic targets for the prevention and development of treatments of corneal degeneration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/ICL.0000000000001130 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dry eye disease and morphological changes in the anterior chamber in people with cystic fibrosis.
J Cyst Fibros
January 2025
Pulmonology Department, Regional University Hospital of Malaga, Department of Medicine and Dermatology, University of Malaga, Biomedical Research Institute of Malaga (IBIMA) - Bionand Platform, Malaga, Spain. Electronic address:
Background: Cystic fibrosis (CF) is caused by variants in a gene that encodes a protein essential for water and ion transport in the epithelial cells of exocrine organs. Given the possible relationship of this protein and conjunctival and corneal epithelium, the aim of this study was to evaluate ophthalmologic alterations in people with CF.
Methods: Forty-five people with CF underwent pulmonary evaluation including inflammatory score (IS).
A deep dive into radiation keratopathy; Going beyond the current frontiers.
Exp Eye Res
January 2025
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address:
Radiotherapy is one of the conventional treatments for head and neck malignancies. Despite the implementation of protective measures to minimize the detrimental impact on healthy tissues surrounding the radiation site, radiation keratopathy remains a prevalent complication. We aimed to establish a mouse model of radiation keratopathy to characterize the pathophysiology of the disease and enable future identification of potential treatments.
View Article and Find Full Text PDFPenetrating orbital trauma: Comprehensive review and meta-analysis of bullet injuries.
Surg Neurol Int
December 2024
Department of Surgery, Baghdad Teaching Hospital, Baghdad, Iraq.
Background: Orbital bullet injuries resulting from high-velocity trauma pose significant clinical challenges due to the potential for severe ocular and systemic complications. This meta-analysis consolidates the existing body of knowledge on direct orbital bullet injuries with respect to clinical outcomes, management strategies, and long-term effects.
Methods: The literature search was conducted by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, using databases such as PubMed and Scopus.
Decellularization of fish tissues for tissue engineering and regenerative medicine applications.
Regen Biomater
November 2024
Zhejiang Top-Medical Medical Dressing Co. Ltd, Wenzhou, Zhejiang 325025, China.
Decellularization is the process of obtaining acellular tissues with low immunogenic cellular components from animals or plants while maximizing the retention of the native extracellular matrix structure, mechanical integrity and bioactivity. The decellularized tissue obtained through the tissue decellularization technique retains the structure and bioactive components of its native tissue; it not only exhibits comparatively strong mechanical properties, low immunogenicity and good biocompatibility but also stimulates neovascularization at the implantation site and regulates the polarization process of recruited macrophages, thereby promoting the regeneration of damaged tissue. Consequently, many commercial products have been developed as promising therapeutic strategies for the treatment of different tissue defects and lesions, such as wounds, dura, bone and cartilage defects, nerve injuries, myocardial infarction, urethral strictures, corneal blindness and other orthopedic applications.
View Article and Find Full Text PDFPositional lagophthalmos variability in facial nerve palsy with and without upper eyelid loading.
Orbit
January 2025
Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
Purpose: Lagophthalmos from facial nerve palsy is traditionally measured with patients in an upright position and may fail to identify positional variability. This study aims to assess the effects of body position, surgical technique, implant material, and patient demographics on lagophthalmos.
Methods: A multicenter prospective study was performed to evaluate positional changes in paralytic lagophthalmos and the effects of various patient and surgical factors.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!