Actinomyces can cause severe infections in the gynecological tract, such as pelvic inflammatory disease (PID) and tubo-ovarian abscess. It's essential to accurately diagnose actinomycotic granules (AMGs) in gynecological specimens to ensure proper treatment, significantly differentiating them from pseudoactinomycotic radiate granules (PAMRAGs), a non-pathologic condition. This article describes a case of a 61-year-old postmenopausal woman with an intrauterine device (IUD) who was diagnosed with PAMRAGs in an endometrial biopsy specimen. This case highlights the challenges in diagnosis, emphasizing the need to understand the distinguishing features and staining properties of PAMRAGs and AMGs to avoid diagnostic errors and awareness of the histological distinguishing features and staining properties of PAMRAGs and AMGs to avert diagnostic mistakes.
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Pseudoactinomycotic Radiate Granules in the Gynecological Tract: A Case Report.
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Actinomyces can cause severe infections in the gynecological tract, such as pelvic inflammatory disease (PID) and tubo-ovarian abscess. It's essential to accurately diagnose actinomycotic granules (AMGs) in gynecological specimens to ensure proper treatment, significantly differentiating them from pseudoactinomycotic radiate granules (PAMRAGs), a non-pathologic condition. This article describes a case of a 61-year-old postmenopausal woman with an intrauterine device (IUD) who was diagnosed with PAMRAGs in an endometrial biopsy specimen.
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J Coll Physicians Surg Pak
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Department of Orthopaedia and Traumatology, Faculty of Medicine, Recep Tayyip Erdogan University, Turkey.
Pseudoactinomycotic radiate granules (PAMRAGs) are most frequently observed in female genitalia. Morphologically, these closely resemble the actual actinomycotic granules. Actinomyces are infectious organisms that require treatment; whereas, PAMRAGs do not require a specific treatment since they are not infectious.
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Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentristry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
Background: Pseudoactinomycotic radiate granules are biologically inactive formations simulating true actinomycotic granules. They occur mainly in the female genital tract. Here we describe a previously unreported case of these granules in a maxillary sinus.
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Pseudoactinomycotic radiate granules (PAMRAGs) are rarely detected lesions in ovary. Endometrium is the usual site and a detailed search of literature yielded only two cases in the ovary. PAMRAGs must be differentiated from actinomycotic granules which are also strongly associated with the use of intrauterine contraceptive devices (IUCDs).
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Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BA, Northern Ireland, UK.
Background: Both actinomycotic granules and pseudoactinomycotic radiate granules (PAMRAGs) occur in the female genital tract, most commonly in the endometrium. It is important to distinguish between these since the former may result in pelvic inflammatory disease and require antibiotic treatment while the latter is non-infectious and does not require specific treatment.
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