AI Article Synopsis
- Leukemia, a common and serious childhood cancer, has a poor prognosis, and targeting immune checkpoints might offer new treatment options.
- A study assessed T cells in pediatric leukemia patients, finding higher levels of a specific type of immune cell (CD103CD8 T cells) in those who achieved complete remission compared to those who relapsed, with lower levels of exhaustion markers like PD-1.
- The results suggest that monitoring these T cell characteristics could help predict treatment outcomes in leukemia patients and guide future therapies.
Article Abstract
Background: Leukemia is a prevalent pediatric life-threatening hematologic malignancy with a poor prognosis. Targeting immune checkpoints (ICs) to reverse T cell exhaustion is a potentially effective treatment for leukemia. Tissue resident memory T (T) cells have been found to predict the efficacy of programmed death receptor-1 inhibitor (anti-PD-1) therapy in solid tumors. However, the IC characteristics of T cells in leukemia and their relationship with prognosis remain unclear.
Methods: We employed multi-color flow cytometry to evaluate the frequencies of CD103CD4 and CD103CD8 T cells in the peripheral blood (PB) of patients with acute myeloid leukemia and B-cell acute lymphoblastic leukemia compared to healthy individuals. We examined the expression patterns of PD-1 and T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) within the circulating CD103 T cell subsets affected by leukemia. To further elucidate the immunological landscape, we assessed the differentiation status of CD103 T cells across various disease states in patients with leukemia.
Results: Our findings showed a significant increase in the frequency of CD103CD8 T cells in the PB of patients with leukemia who had achieved complete remission (CR) compared to those in the and relapsed/refractory (RR) stages. This increase was accompanied by a notable decrease in the expression levels of PD-1 and TIGIT in CD103CD8 T cells in the CR stage. Additionally, our analysis revealed a higher proportion of CD103CD8 T cells in the central memory (TCM) and effector memory (TEM) subsets of the immune profile. Notably, the proportions of CD103 naïve T cells, CD103 TEM, and CD103 terminally differentiated T cells within the CD8 T cell population were significantly elevated in patients with CR compared to those in the /RR stages.
Conclusion: The data indicate that circulating higher frequency of CD103CD8 T cells with lower expression of PD-1 and TIGIT are associated with favorable outcomes in patients with leukemia. This suggests a potential role of T cells in leukemia prognosis and provides a foundation for developing targeted immunotherapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465237 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1437726 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CD69CD103CD8 tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer.
Cell Commun Signal
December 2024
Department of General Surgery, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China.
Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate of patient mortality. CD8 tissue-resident memory T (TRM) cells are strategically positioned to mediate effective anti-tumor responses.
View Article and Find Full Text PDFTumor-Infiltrating CD103+ Tissue-Resident Memory T Cells and CD103-CD8+ T Cells in HNSCC Are Linked to Outcome in Primary but not Metastatic Disease.
Clin Cancer Res
January 2024
Liverpool Head and Neck Center, Institute of Systems, Molecular and Integrative Biology and Liverpool CRUK and NIHR Experimental Cancer Medicine Center, UK University of Liverpool, Liverpool, United Kingdom.
Article Synopsis
- High numbers of tumor-infiltrating lymphocytes (TIL), particularly tissue-resident memory T cells (TRM), are associated with better survival rates in cancer patients, especially in primary head and neck squamous cell carcinoma (HNSCC).
- A study analyzed 379 HNSCC cases, finding that heavy alcohol consumption significantly reduced TRM cells in primary tumors and that TRM cell high counts in recurrences improved patient outcomes after 12 months.
- While TRM cell density in lymph node metastases did not correlate with patient outcomes, increased levels of the checkpoint molecule TIM3 were noted, indicating potential for future therapeutic exploration.
Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren's syndrome.
JCI Insight
April 2023
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Primary Sjögren's syndrome (pSS) is a systemic autoimmune inflammatory disease mainly defined by T cell-dominated destruction of exocrine glands. Currently, CD8+ T cells are thought to be involved in the pathogenesis of pSS. However, the single-cell immune profiling of pSS and molecular signatures of pathogenic CD8+ T cells have not been well elucidated.
View Article and Find Full Text PDFImmune profiling identifies CD8 T-cell subset signatures as prognostic markers for recurrence in papillary thyroid cancer.
Front Immunol
November 2022
Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Background: Thyroid tissue has a special immune microenvironment that is not well characterized. Whether immune cells have a prognostic value in the recurrence of papillary thyroid cancer (PTC) needs further investigation.
Methods: Multinodular non-toxic goiter (MNG) was taken as normal tissue for the difficulty in obtaining completely normal thyroid tissue (normal thyroid function, no thyroiditis, and no nodules).
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium.
Immun Ageing
November 2022
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH, 03756, USA.
Background: Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for successful reproduction, and protection against sexually transmitted infections and potential tumors. We have previously demonstrated that EM CD8+ T cell cytotoxicity is suppressed directly and indirectly by sex hormones and enhanced after menopause. What remains unclear is whether CD8+ T cell protection and the contribution of tissue-resident (CD103+) and non-resident (CD103-) T cell populations in the EM change as women age following menopause.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!