nematodes possess expanded families of Hedgehog related (Hh-r) and Patched/Dispatched-related (PTR) proteins but their functional relationship remains unclear. Here we investigated whether CHE-14 , the closest ortholog for the Hedgehog transporter Dispatched, was necessary for the secretion of two tagged Hh-r proteins: WRT-10 and GRL-2 . We report that CHE-14 is dispensable for the apical localization of GRL-2 and WRT-10 . We also show that animals lacking CHE-14 and another redundant PTR protein DAF-6 also secrete WRT-10 , suggesting neither are required for secretion of these specific Hh-r proteins.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465080 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001329 | DOI Listing |
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