Background: The application of nanotechnology in the molecular diagnosis and treatment of cancer is essential.
Objective: This study aimed to investigate the influence of curcumin-coated ultra-small superparamagnetic iron oxide (USPIO) as a T contrast agent in Magnetic Resonance Imaging (MRI).
Material And Methods: In this experimental study, the influence of curcumin-coated USPIO (FeO@C) on the diagnosis of the cancer cell line was investigated. After synthesis, characterization, and relaxation of FeO@C, the contrast changes in T-weight MRI to mouse colon carcinoma 26 cell line were evaluated in vitro.
Results: FeO@C nanoparticles (NPs) are good at imaging; based on a relaxometry test, the r and r relaxivities of Dotarem were 3.139 and 0.603 mMs, respectively. Additionally, the r and r relaxivities of FeO@C were 3.792 and 1.3 mMs, respectively, with the rate of 2.155 of r/r NPs.
Conclusion: The NPs can be identified as a positive contrast agent with a weight of T in MRI. The coresh-ell FeO@C NPs can be effective in cancer treatment and diagnosis because of the therapeutic effects of curcumin and the properties of USPIO.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462277 | PMC |
| http://dx.doi.org/10.31661/jbpe.v0i0.2201-1447 | DOI Listing |
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