AI Article Synopsis
- A new method for efficiently opening imidazoheterocycles through direct C-H azidation has been developed, leading to the formation of N-heterocyclic amides.
- This process uses convergent paired electrolysis, allowing for the creation of a variety of pyridylbenzamides with yields ranging from moderate to excellent, all without the need for external oxidants, electrolytes, or metals.
- The methodology has been adapted to continuous flow conditions, resulting in significant cost savings compared to traditional batch processing methods.
Article Abstract
An efficient ring opening of imidazoheterocycles induced by a direct C-H azidation resulting in an unusual formation of N-heterocyclic amides has been successfully developed through convergent paired electrolysis. A broad scope of pyridylbenzamides could be obtained in moderate to excellent yields under exogenous-oxidant, electrolyte- and metal-free electrochemical conditions. The methodology was transferred to continuous flow conditions resulting in notable improvements particularly in terms of cost-efficiency over traditional batch versions.
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| http://dx.doi.org/10.1039/d4ob01115e | DOI Listing |
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