AI Article Synopsis
- * The micelle, named PE@PPH, enhances the transport and localization of therapeutic proteins to cancer cells, potentially improving treatment effectiveness.
- * Results show that PE@PPH exhibits significant antitumor effects even at low doses, indicating its potential as a promising strategy for overcoming challenges like tumor heterogeneity in breast cancer.
Article Abstract
The gene is commonly mutated in breast cancer, protein based the gene as anticancer drugs could provide efficient and stable advantages by restoring the function of the wild-type P53 protein. In this study, we describe the creation and utilization of a micelle composed by natural phycocyanin and paclitaxel and grafting anti-HER2 (PPH), which effectively packages and transports recombinant P53 protein with anti-ER (PE), resulting in a new entity designated as PE@PPH, to address localization obstacles and modify cellular tropism to the cell membrane or nucleus. The results indicate that PE@PPH has strong antitumor properties, even at low doses of PTX both and . These findings suggest that PE@PPH could be an enhancing micelle for delivering therapeutic proteins and promoting protein functional recovery, particularly in addressing the challenges posed by tumor heterogeneity in breast cancer.
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| http://dx.doi.org/10.1021/acsbiomaterials.4c00756 | DOI Listing |
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