AI Article Synopsis
- Reductive deoxygenation of alcohols is difficult due to strong C-OH bonds and the hydroxyl group's poor ability to leave.
- This study presents a method using PhP═O as a catalyst to reduce benzyl alcohols with PhSiH in 30 minutes, even in the presence of air.
- The use of a catalytic amount of PhP═O makes this method more practical for application.
Article Abstract
Reductive deoxygenation of alcohols is particularly challenging because of the high bond dissociation energy of the C-OH bond and the poor leaving ability of the hydroxyl group. Herein we describe a PhP═O-catalyzed reductive deoxygenation of benzyl alcohols with PhSiH under an air atmosphere within 30 min of reaction time. The use of catalytic loading of PhP═O enhances the practicality of this protocol.
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| http://dx.doi.org/10.1021/acs.joc.4c01847 | DOI Listing |
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