AI Article Synopsis
- - The study investigates the anti-inflammatory properties of piperine (PPN) by inducing inflammation in young chicks and administering PPN with various other drugs to compare effects.
- - Results show that PPN effectively reduces inflammation indicators, like licking frequency and paw swelling, in a dose-dependent manner; however, it also reduces the effectiveness of concurrent medications celecoxib (CXB) and ketoprofen (KPN).
- - PPN demonstrates a strong binding affinity to the COX-2 enzyme, suggesting its mechanism of action involves COX-2 inhibition, leading to its anti-inflammatory effects in chicks while competing with other anti-inflammatory drugs.
Article Abstract
This study evaluates the anti-inflammatory effects of a natural product, piperine (PPN), using and methodologies. In the segment, inflammation was induced in the right hind paw of young chicks a formalin (50 μL) injection. PPN was orally administered at doses of 25 and 50 mg/kg with or without celecoxib (CXB) and/or ketoprofen (KPN) (42 mg/kg). The vehicle acted as the negative control group (NC). The analysis predicted the drug-likeness, pharmacokinetics, and toxicity profile of PPN, along with evaluating its binding affinity and ligand-receptor interactions. Results indicate that PPN significantly ( < 0.05) reduced licking frequency and paw edoema in a dose-dependent manner. However, in combination therapy, PPN diminished the effects of both CXB and KPN. PPN showed high affinity (-8.6 kcal/mol) towards the COX-2 enzyme. Therefore, PPN exerts anti-inflammatory effects in chicks through COX-2 inhibition pathways and antagonises CXB and KPN activities.
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| http://dx.doi.org/10.1080/14786419.2024.2413039 | DOI Listing |
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