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Short and long-term outcomes of arterial and caval replacement during postchemotherapy retroperitoneal lymph node dissection in metastatic testicular cancer. | LitMetric

AI Article Synopsis

  • The study focuses on the outcomes of patients with metastatic testicular cancer who underwent retroperitoneal lymph node dissection (RPLND) and major vascular resections between 2000 and 2020.
  • Of the 2,054 patients analyzed, 41 required vascular procedures, with a notable percentage experiencing complications and a median overall survival of 14.9 months.
  • Despite high recurrence rates post-surgery, the findings suggest that these complex surgeries could provide a survival benefit for patients with limited treatment options, achieving a 45% survival rate at 2 years.

Article Abstract

Background And Objective: For patients with metastatic testicular cancer undergoing retroperitoneal lymph node dissection (RPLND), the burden of metastatic disease can require consideration for resection and replacement of major vessels despite chemotherapy. We aimed to clarify the outcomes for patients undergoing these major vascular procedures in a modern era.

Methods: Between 2000 and 2020, 2,054 patients with metastatic testicular cancer underwent a PC-RPLND; of those men, 41 also underwent an aortic, iliac, and/or inferior vena cava (IVC) resection. For men who required a vascular resection, clinicopathologic and operative details were collected. Kaplan-Meier curves were generated to estimate overall survival.

Results: The median preoperative mass size was 9cm in the retroperitoneum. Viable malignancy or teratoma was present in 85% of resected specimens. Following PC-RPLND and vascular resection, 22 (54%) patients recurred. The median (IQR) time to relapse was 4.6 (2.5-8.0) months. 18 (44%) patients died of disease. The overall complication rate was 56%. Ten (24%) patients had Clavien-Dindo III/IV complications, with 2 postoperative mortalities. The median overall survival was 14.9 months. Among the 41 patients, 18 patients had re-operative PC-RPLND and vascular resection; the re-operative PC-RPLND patients had significantly worse survival compared to initial attempt at PC-RPLND (9.3 vs. 162 months, P = 0.03).

Conclusions: The overall survival rate for patients undergoing PC-RPLND with resection of the aorta, IVC, and/or iliac artery is 45% at 2 years. For patients with limited treatment options, these complex surgeries may offer survival benefit with an acceptable morbidity profile.

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Source
http://dx.doi.org/10.1016/j.urolonc.2024.09.022DOI Listing

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