AI Article Synopsis
- - Aspergillosis is a serious infection that can occur in individuals with weakened immune systems, primarily affecting the lungs but sometimes spreading to the skin and other areas in severe cases.
- - A 76-year-old woman with a relapse of a certain autoimmune disease and undergoing immunosuppressive treatment developed skin lesions, which were diagnosed as invasive cutaneous aspergillosis through a biopsy.
- - The patient improved significantly after being treated with voriconazole, highlighting the importance of thorough testing for opportunistic infections in immunocompromised patients presenting with unusual skin symptoms.
Article Abstract
Introduction: Aspergillosis is an opportunistic infection that can complicate any situation of immunosuppression. The primary manifestations are pulmonary, and more rarely, in cases of severe immunosuppression, the infection can become invasive with extra-pulmonary involvement.
Observation: We report the case of a 76-year-old female patient, experiencing a relapse of granulomatosis with polyangiitis treated with corticosteroids, rituximab and cyclophosphamide, who presented with diffuse erythematous nodular skin lesions. A biopsy with histological analysis confirmed a diagnosis of invasive cutaneous aspergillosis. Treatment with voriconazole led to a favorable outcome.
Conclusion: The appearance of skin lesions in an inflammatory context in a patient receiving immunosuppressive therapy should prompt a comprehensive microbiological assessment for opportunistic pathogens, as well as a skin biopsy to investigate for invasive cutaneous aspergillosis.
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| http://dx.doi.org/10.1016/j.revmed.2024.09.005 | DOI Listing |
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