AI Article Synopsis
- Preeclampsia (PE) is a serious pregnancy-related condition that can lead to cardiovascular issues later in life, and this study investigates its impact on arterial stiffness (AS) using specific measurements.
- Conducted in Argentina from 2022 to 2023, the study compares two groups of women: those who recently had PE and healthy postpartum women, assessing their vascular health within 72 hours after giving birth.
- Results showed that women who experienced PE had significantly higher measures of arterial stiffness (cf-PWV, ao-SBP, and AIx), indicating that they are at a greater risk for developing cardiovascular diseases in the future.
Article Abstract
Introduction: Preeclampsia (PE) is a complication of hypertensive disorders of pregnancy, whose pathophysiology involves endothelial dysfunction. Early establishment of subclinical vascular lesions such as arterial stiffness (AS) could explain the development of cardiovascular disease later in life. AS can be assessed non-invasively using carotid-femoral pulse wave velocity (cf-PWV), aortic systolic blood pressure (ao-SBP) and augmentation index (IAx). We aim to determine cf-PWV, ao-SBP and AIx in women who recently underwent PE and compare it with a control group.
Materials And Methods: Cross-sectional study, carried out from 2022 to 2023 in Argentina. Group 1: women who developed PE.
Exclusion Criteria: history of chronic hypertension, diabetes, autoimmune disease, chronic kidney disease, cardiovascular disease, PE in previous pregnancies; treatment with calcium antagonists during pregnancy; treatment with calcium antagonists, angiotensin-converting enzyme inhibitors or diuretics in the postpartum period. Group 2: healthy postpartum periods. PWV-cf, ao-SBP and IAx were measured in the first 72hours postpartum using Aortic.
Results: Seventy-onewomen were included: Group 1 (n=30); Group 2 (n=41). Group 1 presented higher PWV-cf=6.70±0.68 vs. 5.41±0.48 m/s (P<.0001); ao-SBP=118.3±9.6 vs. 101.2±9.8mmHg (P<.0001); and IAu=22.7±10.7 vs. 9.3±11.9% (P<.0001). In Group 1 there were 25 of 30 women who presented AS parameters (OR=8.50; 95% CI=3.32-15.29; P<.0001).
Conclusion: Patients with a recent history of PE showed higher cf-PWV, ao-SBP and AIx values, compatible with AS.
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| http://dx.doi.org/10.1016/j.hipert.2024.07.007 | DOI Listing |
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