AI Article Synopsis
- Starvation therapy aims to disrupt the high energy needs of tumor cells by reducing glucose availability and blocking alternative energy sources.
- This approach utilizes glucose oxidase (GOx) to convert glucose into gluconic acid and hydrogen peroxide, prompting tumor cells to use other substrates like amino acids and fatty acids.
- Combining GOx with chemotherapy, phototherapy, or immunotherapy, alongside targeted delivery using nanoformulations, can enhance the effectiveness of cancer treatment by improving tumor cell elimination.
Article Abstract
Starvation therapy targets the high metabolic demand of tumor cells. It primarily leans over the consumption of intracellular glucose and simultaneous blockade of alternative metabolic pathways. The strategy involves the use of glucose oxidase (GOx) for catalyzing the conversion of glucose into gluconic acid and hydrogen peroxide. Under these conditions, metabolic re-programming of tumor cells enables the utilization of substrates such as amino acids, fatty acids and lipids. This can be overcome by co-administration of chemo-, photo- and immuno-therapeutics together with glucose oxidase. Targeted delivery of glucose oxidase at tumor site can be enabled with the use of nanoformulations. In this review, we highlight that the outcomes of starvation therapy can be improved using rationally developed nano-formulations. It is possible to load synergistically acting bioactives in these formulations and deliver in site-specific manner and hence achieve the elimination of tumors cells with greater efficacy.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.136444 | DOI Listing |
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