AI Article Synopsis
- We are regularly exposed to various environmental pollutants, but advancements in stem cell toxicology are providing better research opportunities in understanding their effects.
- By using stem cell technology, we can improve the prediction of how toxic these pollutants are compared to traditional methods, although there's still room for improvement in detection processes.
- Our study developed a detection model using TBXT-EGFP iPS cells to screen 38 common environmental pollutants, revealing that some, like TBBPA-BDBPE and TBBPA-BHEE, could disrupt essential genes involved in early human embryo development, potentially leading to developmental issues.
Article Abstract
In our daily lives, we are inevitably exposed to a variety of environmental pollutants in numerous ways. Fortunately, recent years have witnessed significant advancements in the field of stem cell toxicology, which have provided new opportunities for research in environmental toxicology. Applying stem cell technology to environmental toxicology, overcomes some of the limitations of traditional screening methods and we can more accurately predict the toxicity of environmental pollutants. However, there are still several aspects of stem cell toxicology models that require improvement, such as increasing the throughput of detection and simplifying detection methods. Consequently, we developed an environmental pollutant toxicity detection model based on TBXT-EGFP iPS cells and screened the developmental toxicity of 38 typical environmental pollutants. Our results indicate that TBBPA-BDBPE, TBBPA-BHEE, DG, and AO2246 may interfere with the expression of TBXT, a critical marker gene for early human embryo development, implying that these environmental pollutants could lead to developmental abnormalities.
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| http://dx.doi.org/10.1016/j.fct.2024.115039 | DOI Listing |
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