AI Article Synopsis
- RSV is more severe in infants than in adults, but the reasons for this difference are not fully understood.
- Researchers used nasal organoid models from both infants and adults to explore how their nasal linings respond to RSV infection.
- The study found that infant nasal cells had a stronger viral response, more mucus production, and greater cell damage, suggesting that infants’ immune responses might lead to more severe infections than in adults.
Article Abstract
Background: Respiratory syncytial virus (RSV) causes significant morbidity and mortality, especially in young children. Why RSV infection in children is more severe compared to healthy adults is not fully understood.
Methods: We used ex-vivo human nasal organoid platforms from infants and adults to investigate the underlying mechanism of this disease disparity at the initial site of RSV replication, the nasal epithelium.
Results: Infant-derived human nasal organoid-air liquid interface (HNO-ALIs) lines were more susceptible to early RSV replication. Moreover, infant-derived HNO-ALIs elicited a statistically significant greater overall cytokine response, enhanced mucous production, and greater cellular damage compared to their adult counterparts. Furthermore, the adult cytokine response was associated with a superior regulatory cytokine response, which could explain less cellular damage than in infant lines.
Conclusions: Our data highlights substantial differences in how infant and adult upper respiratory tract epithelium responds to RSV infection at the cellular level. These differences in epithelial cellular response can lead to impaired mucociliary clearance, a more dysregulated innate immune response predisposing infants to more severe RSV infection compared to adults.
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| http://dx.doi.org/10.1016/j.jinf.2024.106305 | DOI Listing |
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