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Key Laboratory of Molecular Biophysics, Institute of Biophysics, School of Health Sciences & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China.
Brain diseases pose significant treatment challenges due to the restrictive nature of the blood-brain barrier (BBB). Recent advances in targeting macromolecules offer promising avenues for overcoming these obstacles through receptor-mediated transcytosis (RMT). We summarize the current progress in targeting brain drug delivery with macromolecules for brain diseases.
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Department of Mechanical Engineering, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
Metamaterials are pushing the limits of traditional materials and are fascinating frontiers in scientific innovation. Mechanical metamaterials (MMs) are a category of metamaterials that display properties and performances that cannot be realized in conventional materials. Exploring the mechanical properties and various aspects of vibration and damping control is becoming a crucial research area.
View Article and Find Full Text PDFState of the Art of Primary PCI: Present and Future.
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Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York, NY 10467, USA.
Primary percutaneous coronary intervention (PCI) has revolutionized the management of ST-elevation myocardial infarction (STEMI), markedly improving patient outcomes. Despite technological advancements, pharmacological innovations, and refined interventional techniques, STEMI prognosis remains burdened by a persistent incidence of cardiac death and heart failure (HF), with mortality rates plateauing over the last decade. This review examines current practices in primary PCI, focusing on critical factors influencing patient outcomes.
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Laboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, Brazil.
Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates.
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College of Computer Science and Cyber Security (Pilot Software College), Chengdu University of Technology, Chengdu 610059, China.
The photocatalytic oxidative coupling of methane (OCM) on metal-loaded one-dimensional TiO nanowires (TiO NWs) was performed. With metal loading, the electric and optical properties of TiO NWs were adjusted, contributing to the improvement of the activity and selectivity of the OCM reaction. In the photocatalytic OCM reaction, the 1.
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