AI Article Synopsis
- - Paneth cells in the intestinal crypts help support stem cells and immunity by producing growth factors and antimicrobial peptides.
- - A study by Wallaeys et al. discusses how these Paneth cells respond to TNF (tumor necrosis factor), which affects their ability to manage stress in proteins.
- - This disruption leads to a decrease in antimicrobial peptides, increasing the risk of bacteria moving into the bloodstream and potentially causing sepsis.
Article Abstract
Paneth cells located within intestinal crypts support epithelial stem cells and immunity through growth factors and antimicrobial peptides. In this issue of Cell Host & Microbe, Wallaeys et al. report that TNF sensing by Paneth cells disrupts the unfolded protein response and decreases antimicrobial peptides, causing bacterial translocation and sepsis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chom.2024.09.005 | DOI Listing |
Publication Analysis
Top Keywords
paneth cells
8
antimicrobial peptides
8
sense sense
4
sense paneth
4
paneth cell
4
cell regulation
4
regulation mucosal
4
mucosal immunity
4
immunity paneth
4
cells located
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!