AI Article Synopsis
- Diorganotin acylhydrazone complexes show promise as alternatives to platinum-based drugs due to their strong anticancer effects.
- Twelve such complexes were synthesized using a quick "one-pot" microwave method and thoroughly analyzed using various techniques like FT-IR and NMR.
- Among the tested complexes, complex 8 was most effective against HepG2 cancer cells, demonstrating its ability to induce cell death through mitochondrial pathways and halt the cell cycle at the G2/M phase.
Article Abstract
Diorganotin acylhydrazone complexes with mitochondrial targeting demonstrate significant potential as replacements for platinum-based complexes due to their potent anticancer properties. Twelve methylphenyltin arylformylhydrazone complexes have been synthesized by microwave "one-pot" reaction. The complexes have been characterized by FT-IR, multinuclear NMR (H, C, and Sn), TGA, and HRMS. Crystal structures were determined for 10 out of the 12 complexes under study. Structures 1 through 8, 10 and 12 possessed a central symmetric structure of a di-nuclear SnO tetrahedral ring. All complexes were tested for their inhibitory activity against human cell lines NCI-H460, MCF-7, and HepG2. Complex 8 exhibited the most effective inhibitory effect on HepG2 cells, with an IC value of 1.34 ± 0.04 μM. Preliminary studies on the anticancer mechanism suggest that complex 8 induces apoptosis in HepG2 cells via the mitochondrial pathway, accompanied by G2/M phase cell cycle arrest.
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| http://dx.doi.org/10.1016/j.jinorgbio.2024.112756 | DOI Listing |
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- Diorganotin acylhydrazone complexes show promise as alternatives to platinum-based drugs due to their strong anticancer effects.
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- Among the tested complexes, complex 8 was most effective against HepG2 cancer cells, demonstrating its ability to induce cell death through mitochondrial pathways and halt the cell cycle at the G2/M phase.
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