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DAMPs, PAMPs, NLRs, RIGs, CLRs and TLRs - Understanding the Alphabet Soup in the Context of Bone Biology.
Curr Osteoporos Rep
January 2025
Department of Immunology, Tufts University, Boston, MA, 02111, USA.
Purpose Of Review: The purpose of this review is to summarize the current understanding of cell-autonomous innate immune pathways that contribute to bone homeostasis and disease.
Recent Findings: Germ-line encoded pattern recognition receptors (PRRs) are the first line of defense against danger and infections. In the bone microenvironment, PRRs and downstream signaling pathways, that mount immune defense, interface intimately with the core cellular processes in bone cells to alter bone formation and resorption.
AI based medical imagery diagnosis for COVID-19 disease examination and remedy.
Sci Rep
January 2025
Rad. Eng. Dept., National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
COVID-19, caused by the SARS-CoV-2 coronavirus, has spread to more than 200 countries, affecting millions, costing billions, and claiming nearly 2 million lives since late 2019. This highly contagious disease can easily overwhelm healthcare systems if not managed promptly. The current diagnostic method, Molecular diagnosis, is slow and has low sensitivity.
View Article and Find Full Text PDFA Pilot Randomized Controlled Trial to Examine the Impact of a Therapy Dog Intervention on Loneliness in Hospitalized Older Adults.
Innov Aging
September 2024
Department of Clinical Sciences, Center for Animals and Public Policy, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Background And Objectives: Loneliness is linked to significant health threats and is potentially more dangerous than obesity; it affects as many as 29% of noninstitutionalized older adults. Loneliness is exacerbated for those who require inpatient rehabilitation, are displaced from their social networks, spend little time receiving therapy, and are physically inactive and socially isolated. Emerging evidence suggests that companion animals provide a number of health and well-being benefits and that interacting with a trained therapy dog may reduce loneliness.
View Article and Find Full Text PDFPolycyclic Aromatic Hydrocarbons Burden of Meats Singed with Different Fuel Sources from Abattoirs in Ghana and Associated Cancer Risk Assessment.
Environ Health Insights
January 2025
African Centre of Excellence for Public Health and Toxicological Research, University of Port Harcourt, Port Harcourt, Nigeria.
Article Synopsis
- The study analyzed the levels of polycyclic aromatic hydrocarbons (PAHs) in cattle and goat meats cooked with firewood, Liquefied Petroleum Gas (LPG), or tyres across five cities in Ghana.
- Tyre-singed meats showed significantly higher PAHs, specifically the carcinogen benzo[a]pyrene, compared to those singed with firewood and LPG.
- Findings indicate serious health risks from consuming tyre-singed meats, highlighting the need for better regulations and public awareness about PAH exposure.
Clinical practice in an age of medical misinformation and conspiracy theories.
Intern Med J
January 2025
NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Medical misinformation (false health or medical-related information) has seen a rapid increase in volume recently, with the global surge in social media usage and further exacerbation by the COVID-19 pandemic. This may put more lives at stake, as misinformation is an often-cited reason that people make dangerous health choices, engage in harmful practices and reject beneficial health treatments. In this article, we explore the drivers and consequences, as well as suggest several strategies at the personal, educational and systemic level, for physicians to guide and communicate with patients who subscribe to medical misinformation.
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