Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pmic.202300645 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Growth and physiological response of Yulu to drought stress and its omics analysis.
Plant Signal Behav
December 2024
College of Forestry, Hebei Agricultural University, Baoding, Hebei, China.
) is the primary tree species known for its ecological and economic benefits in arid and semi-arid regions. Understanding the response of roots to drought stress is essential for promoting the development of varieties. One-year-old Yulu was utilized as the experimental material, and three water gradients were established: control (CK), moderate (T1) and severe (T2), over a period of 120 days.
View Article and Find Full Text PDFMethodologies for Mitochondrial Omic Profiling During Spaceflight.
Methods Mol Biol
November 2024
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
To be able to understand how spaceflight can affect human biology, there is a need for maximizing the amount of information that can be obtained from experiments flown to space. Recently there has been an influx of data obtained from astronauts through multi-omics approaches based on both governmental and commercial spaceflight missions. In addition to data from humans, mitochondrial specific data is gathered for other experiments from rodents and other organisms that are flown in space.
View Article and Find Full Text PDFProteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination.
PLoS One
November 2024
State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Long-term exposure to a microgravity environment leads to structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms of cardiac damage under microgravity conditions, comprehensive research on changes at the protein level in these hearts is still lacking. In this study, proteomic analysis of microgravity-exposed hearts identified 156 differentially expressed proteins, and ubiquitinomic analysis of these hearts identified 169 proteins with differential ubiquitination modifications.
View Article and Find Full Text PDFAstronaut proteomics: Japan leads the way for transformative studies in space.
Proteomics
October 2024
Heritage College of Osteopathic Medicine, Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, Ohio, USA.
Spatial proteomic profiling elucidates immune determinants of neoadjuvant chemo-immunotherapy in esophageal squamous cell carcinoma.
Oncogene
September 2024
Department of Medical Oncology, Senior Department of Oncology, Chinese PLA General Hospital, The Fifth Medical Center, Beijing, China.
Article Synopsis
- Esophageal squamous cell carcinoma (ESCC) poses serious treatment challenges, prompting a Phase II clinical trial to evaluate a new neoadjuvant chemo-immunotherapy combining PD-1 blockade, nab-paclitaxel, and S-1 for locally advanced cases.
- The trial involved 60 patients, showing promising results with a major pathological response in 62% and complete response in 29%, alongside advanced imaging techniques to analyze the tumor microenvironment.
- Utilizing machine learning, researchers discovered crucial spatial patterns of immune cells that predict treatment outcomes, highlighting the importance of spatial proteomics for personalized cancer therapy in ESCC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!