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Four Opportunities To Revitalize The US Biomedical Research Enterprise.
Health Aff (Millwood)
January 2025
Victor J. Dzau, National Academy of Medicine, Washington, D.C.
The US biomedical research enterprise is renowned for its historical and ongoing scientific breakthroughs and advancements. Yet its capacity to solve complex health issues, bridge health equity gaps, and strengthen public trust is constrained by the lack of an overarching national vision, fragmented coordination for research funding, and critical workforce recruitment and retention challenges. To improve national health outcomes and retain global competitiveness, the sector must embrace new approaches.
View Article and Find Full Text PDFTargeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.
Proc Natl Acad Sci U S A
January 2025
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led to a better understanding of EPN subtypes and revealed a critical role of oncogenes ZFTA-RELA fusion and EPHB2 in supratentorial ependymoma (ST-EPN). However, the immune system's role in tumor progression and response to therapy remains poorly understood.
View Article and Find Full Text PDFExploring the experiences of minoritised groups at life sciences conferences in the UK: new perspectives and actions to improve inclusivity in the sector.
Wellcome Open Res
March 2024
Sea-Change Consultancy, London, SE10 0TS, UK.
Attending and participating in scientific research meetings and conferences is a key mechanism for researchers to share information and knowledge, build networks, and establish relationships and collaborations to support career development. In the UK, researchers from minoritised or underrepresented groups, may have a different experience at a conference than their peers. As a high profile provider of genomics-focussed life science conferences, Wellcome Connecting Science is committed to ensuring that our events are as inclusive as possible.
View Article and Find Full Text PDFChallenges and opportunities of artificial intelligence in African health space.
Digit Health
January 2025
Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
The application of artificial intelligence (AI) to healthcare in Africa has the potential to transform productivity, diagnosis, disease surveillance, and resource allocation by improving accuracy and efficiency. However, to fully realize its benefits, it is necessary to consider issues concerning data privacy, equity, infrastructure integration, and ethical policy development. The use of these tools may improve the detection of diseases, the distribution of resources, and the continuity of care.
View Article and Find Full Text PDFInvesting in an Olympic agenda: from Rio to Tokyo and beyond.
Front Sports Act Living
January 2025
School of Management, Canadian University Dubai, Dubai, United Arab Emirates.
Context: This study was inspired by the considerable risks and diminishing enthusiasm among societies to invest in Olympic agendas, which traditionally involve billions of dollars, various opportunities, and complexities for host countries.
Purpose: The objective of this study was to evaluate the risks and benefits of long-term equity investments for companies and governments engaged in the Olympic movement.
Method: Qualitative methodologies were employed for this research, utilizing a multi-case approach that included 38 comprehensive interviews with companies and entities impacted by the Rio 2016 and Tokyo 2020 Olympic Games.
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