AI Article Synopsis
- - The study focuses on a female patient with recurrent visceral leishmaniasis who was diagnosed with IL-12Rβ1 deficiency, a condition that affects the immune system and increases susceptibility to infections.
- - It highlights the patient's history, including receiving the BCG vaccine and developing visceral leishmaniasis at 91 months, and examines her diagnosis and treatment retrospectively.
- - The findings suggest that IL-12Rβ1 deficiency may lead to recurrent infections like visceral leishmaniasis, emphasizing the need for immunological evaluation in patients with this diagnosis.
Article Abstract
Purpose: In this study, we present the case of a children who was followed up for recurrent visceral leishmaniasis and diagnosed with IL-12Rβ1 deficiency.
Methods: A female patient who received Bacille Calmette-Guérin (BCG) vaccine 2 months after birth and developed visceral leishmaniasis at the age of 91 months was subsequently diagnosed with IL-12Rβ1 deficiency. The patient's diagnosis and treatment process were examined retrospectively.
Results: IL-12Rβ1 deficiency is an autosomal recessive disease characterized by susceptibility to recurrent and/or severe infections caused by weakly pathogenic mycobacteria and salmonella. Infections with other intramacrophagic organisms may also occur, although rarely. Based on this information, it is believed that the mutation in the IFN-γ/IL-12 axis in our patient predisposed her to recurrent Leishmania infections.
Conclusion: This study adds to the limited literature on IL12RB1 deficiency as a cause of VL. Patients diagnosed with VL should be evaluated immunologically, as recurrent Leishmania infections may occur in those with IL-12Rβ1 defects.
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| http://dx.doi.org/10.1007/s11686-024-00926-8 | DOI Listing |
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