AI Article Synopsis
- Gas gangrene is a rare but severe infection often caused by the pathogen Clostridium septicum, which can develop either from trauma or spontaneously, particularly in patients with conditions like occult colon carcinoma.
- Individuals with diabetes mellitus are at a higher risk for developing this infection, which has a high mortality rate of around 50%, even with aggressive treatment.
- Initial symptoms are vague, complicating early diagnosis, and treatment typically involves high-dose antibiotics, surgical removal of infected tissue, and sometimes hyperbaric oxygen therapy.
Article Abstract
The full clinical picture of a gas gangrene infection is an absolute rarity. The mechanism of development can be either traumatic or spontaneous (e.g., hematogenous seeding in occult colon carcinoma). In particular, the rare pathogen Clostridium septicum appears to be associated with spontaneously occurring gas gangrene. Diabetes mellitus is a significant risk factor. The mortality rate of the disease is around 50%, even with maximum therapeutic efforts, and the course of the disease is fulminant in the majority of cases. Initial symptoms are unspecific and make early diagnosis difficult. Treatment consists of high-dose antibiotics in combination with radical surgical debridement and, if necessary, supplementary hyperbaric oxygen therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00113-024-01490-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gas gangrene due to Clostridium haemolyticum in a cat with aortic thromboembolism treated using clopidogrel and rivaroxaban.
Aust Vet J
December 2024
Centre for Veterinary Education, Sydney School of Veterinary Science, The University of Sydney, Sydney, Australia.
A 12-year-old Bengal cat with unclassified cardiomyopathy presented for signs consistent with aortic thromboembolism (ATE). It was treated with clopidogrel and rivaroxaban as antithrombotic therapy, combined with narcotic analgesia and frusemide. After initially making a clinical improvement, the cat's condition suddenly deteriorated, with a presumptive diagnosis of clostridial myonecrosis.
View Article and Find Full Text PDFSurgical Management of Concurrent Septic Arthritis and Forearm Necrotizing Fasciitis in an Immunocompromised Patient With a 20-Year History of Chronic Lymphocytic Leukemia: A Case Report.
Cureus
November 2024
Orthopaedics and Traumatology, Istanbul University Cerrahpasa - Cerrahpasa Faculty of Medicine, Istanbul, TUR.
Shoulder septic arthritis is a severe infection of the shoulder joint, commonly caused by bacteria such as . It leads to inflammation, severe pain, swelling, and reduced mobility in the affected shoulder. The condition is typically diagnosed through clinical evaluation, blood tests, imaging studies, and joint aspiration.
View Article and Find Full Text PDFHydrotherapy to Hospice: The Hidden Perils of Necrotizing Fasciitis Mimicry in Elderly Patients.
Cureus
November 2024
Trauma and Orthopaedics, Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Aylesbury, GBR.
This case report presents a 77-year-old female with dementia and hypertension who experienced reduced consciousness during hydrotherapy. She was found to have hypotension, a low Glasgow Coma Scale score, and right thigh pain. Blood work showed acute kidney injury and elevated inflammatory markers, while imaging revealed surgical emphysema in the right thigh and pelvis without trauma.
View Article and Find Full Text PDFThe mystery of abdominal snow-grip sensation: emphysematous cystitis complicated with bladder gangrene and rupture-case report and literature review.
Front Med (Lausanne)
November 2024
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Emphysematous cystitis (EC) refers to a rare form of complicated urinary tract infection (UTI), which is typically observed in elderly females with severe diabetes mellitus. EC was triggered by bacteria, producing gas filled cysts in the bladder wall and lumen, the most common of which are and . Since EC could be potentially life-threatening, severe form of EC (like septic shock) can cause gangrenous cystitis (GC).
View Article and Find Full Text PDFA Critical Review of Postbiotics as Promising Novel Therapeutic Agents for Clostridial Infections.
Probiotics Antimicrob Proteins
November 2024
Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Clostridial infections, known for their severity and rapid progression, present significant challenges in both clinical and veterinary fields. These bacteria, which can survive without oxygen and produce protective spores, cause many diseases, ranging from simple gastrointestinal disorders to severe and potentially fatal infections including botulism, tetanus, and gas gangrene. The rising occurrence of antibiotic-resistant strains and the repetitive character of some Clostridial illnesses, including Clostridioides difficile infections (CDI), highlight the immediate need for alternate treatment approaches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!