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[Protective effect of Codonopsis Radix fermented with Lactobacillus plantarum on gastric mucosa in rat model of acute gastric ulcer].
Zhongguo Zhong Yao Za Zhi
September 2024
School of Life Sciences, Lanzhou University Lanzhou 730000, China.
This study aims to decipher the mechanism of the broth of Codonopsis Radix fermented with Lactobacillus plantarum(FCR) on the gastric mucosa in the rat model of acute gastric ulcer. A total of 64 SD rats were randomized into 8 groups: control, model, positive control(omeprazole), probiotic, unfermented Codonopsis Radix, and low-, medium-and high-dose FCR, with 8 rats in each group. The rat model of acute gastric ulcer was established by gavage with anhydrous ethanol.
View Article and Find Full Text PDFGenome-wide association studies unveil major genetic loci driving insecticide resistance in Anopheles funestus in four eco-geographical settings across Cameroon.
BMC Genomics
December 2024
Centre for Research in Infectious Diseases (CRID), P.O. BOX 13591, Yaoundé, Cameroon.
Background: Insecticide resistance is jeopardising malaria control efforts in Africa. Deciphering the evolutionary dynamics of mosquito populations country-wide is essential for designing effective and sustainable national and subnational tailored strategies to accelerate malaria elimination efforts. Here, we employed genome-wide association studies through pooled template sequencing to compare four eco-geographically different populations of the major vector, Anopheles funestus, across a South North transect in Cameroon, aiming to identify genomic signatures of adaptive responses to insecticides.
View Article and Find Full Text PDFUnraveling the Metabolic Enigma: A High-Resolution LC-MS Approach to Decipher Two Triazine Herbicides Tolerance in Radish and Rice.
J Agric Food Chem
December 2024
College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Our study investigated the effects of terbuthylazine (TBA) and metribuzin (MT) on rice and radish at field application concentrations. Both herbicides induced oxidative stress and severely inhibited growth in the two crops. However, the radish cultivar T-33 exhibited significantly lower stress levels compared to the sensitive cultivar S-24, suggesting its higher tolerance to TBA and MT.
View Article and Find Full Text PDFDeciphering the Phytochemical Potential of Hemp Hairy Roots: A Promising Source of Cannabisins and Triterpenes as Bioactive Compounds.
Molecules
December 2024
Mibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland.
L., specifically hemp, is a traditional herbaceous plant with industrial and medicinal uses. While much research has focused on cannabinoids and terpenes, the potential of hemp roots is less explored due to bioproduction challenges.
View Article and Find Full Text PDFDeciphering the hepatitis E virus ORF1: Functional domains, protein processing, and patient-derived mutations.
Virology
December 2024
Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, 510642, China. Electronic address:
Hepatitis E virus (HEV) is a major cause of acute and chronic hepatitis in humans. The HEV open reading frames (ORF1) encodes a large non-structural protein essential for viral replication, which contains several functional domains, including helicase and RNA-dependent RNA polymerase. A confusing aspect is that, while RNA viruses typically encode large polyproteins that rely on their enzymatic activity for processing into functional units, the processing of the ORF1 protein and the mechanisms involved remain unclear.
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