Extraskeletal Ewing Sarcoma is a rare tumor of the soft tissues. Primary Ewing Sarcoma of the lung is an exceedingly uncommon variant of Extraskeletal Ewing Sarcoma, with only a small number of cases reported in the literature. We present a case of a 43-year-old woman who presented with a locally invasive mass of the right lung, biopsy-proven to be Ewing Sarcoma.
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http://dx.doi.org/10.1016/j.radcr.2024.09.048 | DOI Listing |
Nat Commun
January 2025
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity with strong phenotypical implications. Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines.
View Article and Find Full Text PDFCurr Opin Otolaryngol Head Neck Surg
December 2024
Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, HBNI, Parel, Mumbai.
Purpose Of Review: Ewing's sarcoma is a small round-cell tumour typically arising in the bones, and only rarely affecting soft tissues. These are rarely seen in the head and neck comprising 1-9% of all cases, making management of these tumours a challenge. This review aims to review the current literature to update the current diagnostic and treatment options in head and neck Ewing's sarcoma.
View Article and Find Full Text PDFNat Commun
January 2025
Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Large-scale combination drug screens are generally considered intractable due to the immense number of possible combinations. Existing approaches use ad hoc fixed experimental designs then train machine learning models to impute unobserved combinations. Here we propose BATCHIE, an orthogonal approach that conducts experiments dynamically in batches.
View Article and Find Full Text PDFScience
January 2025
Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Germline structural variants are a risk factor for pediatric extracranial solid tumors.
View Article and Find Full Text PDFScience
January 2025
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using germline genome sequencing of 1765 affected children, their 943 unaffected parents, and 6665 adult controls. We discovered a sex-biased association between very large (>1 megabase) germline chromosomal abnormalities and increased risk of solid tumors in male children.
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