Objective: Snail slime possesses various pharmacological activities that are becoming attractive for zootherapy, thereby necessitating the profiling of its safety and toxicity. Therefore, using OECD 425 guidelines, this study assessed the acute toxicity of slime extract and performed a histological analysis of the vital organs.
Methods: Eighteen (18) Wistar rats were assigned randomly into three groups: control, 2000 mg/kg, and 5000 mg/kg bw slime extract. The dosing of the animals with 2000 mg/kg bw and 5000 mg/kg bw was done according to the limit test procedure, after which the animals were observed for 14 days. During the observation period, clinical and behavioral changes were recorded. The rats were euthanized after 14 days of monitoring, and their essential organs were excised for gross histological examination.
Results: There was no mortality during the observation period, and the LD of slime extract was determined to be greater than 5000 mg/kg bw. Although there were no behavioral alterations in the rats after oral exposure to the slime extract, the histological examination revealed mild cellular distortions in the rat organs. Furthermore, a preliminary chemical analysis of the slime extract revealed the presence of flavonoids and phenolics.
Conclusion: slime extracts may be grouped as low toxic substance based on the results obtained (LD > 2000 - 5000 mg/kg). However, the histological distortions in rat organs following acute oral exposure to the snail slime extract not only warrant further, in-depth toxicological investigations but also caution in its use for traditional medicinal purposes.
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http://dx.doi.org/10.1016/j.toxrep.2024.101743 | DOI Listing |
ACS Omega
December 2024
Department of Chemical Engineering, İzmir Institute of Technology, Urla, İzmir 35430, Turkey.
In recent years, there has been a notable shift toward exploring plant and animal extracts for the fabrication of tissue engineering structures that seamlessly integrate with the human body, providing both biological compatibility and physical reinforcement. In this particular investigation, we synthesized bilayer wound dressings by incorporating snail () secretions, comprising mucus and slime, into chitosan matrices via lyophilization and electrospinning methodologies. A nanofiber layer was integrated on top of the porous structure to mimic the epidermal layer for keratinocyte activity as well as acting as an antibacterial barrier against possible infection, whereas a porous structure was designed to mimic the dermal microenvironment for fibroblast activity.
View Article and Find Full Text PDFJ Imaging Inform Med
October 2024
Department of Electronics and Communication Engineering, Anurag University, Hyderabad, Telangana, 500088, India.
Osteoarthritis (OA) of the knee is a chronic state that significantly lowers the quality of life for its patients. Early detection and lifetime monitoring of the progression of OA are necessary for preventive therapy. In the course of therapy, the Kellgren and Lawrence (KL) assessment model categorizes the rigidity of OA.
View Article and Find Full Text PDFPlanta Med
November 2024
Department of Pharmaceutical Biology, Medical University of Warsaw, Warsaw, Poland.
Wound infections are a significant medical problem, with species being one of the most common etiological factors. Treatment is complex due to bacterial antibiotic resistance and the ability to form a biofilm. The aim of this study was to determine the drug susceptibility of the clinical isolates of species obtained from wound infections, assess their ability to form a biofilm , evaluate the level of extracellular slime synthesis, and test the antistaphylococcal properties of selected plant extracts against plate-cultured bacteria and activity against mature biofilms.
View Article and Find Full Text PDFToxicol Rep
December 2024
Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Bowen University, PMB 232, Iwo 232101, Nigeria.
BMC Chem
September 2024
Hot Laboratories Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt.
Solvent extraction of selenium(IV) ions from highly concentrated hydrochloric acid using 0.4 mol/L Aliquat 336 dissolved in kerosene was investigated. As a modifying agent, 1-octanol (10% v/v) was added to the organic phase to avoid the third phase formation.
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