AI Article Synopsis
- - Mucormycosis, specifically rhinocerebral mucormycosis (RCM), is a rare and serious fungal infection that is often difficult to diagnose, leading to high mortality rates due to delays.
- - A case study highlighted a patient with both pulmonary aspergillosis and RCM, where the diagnosis was confirmed through advanced metagenomic Next-Generation Sequencing (mNGS), but despite aggressive treatment, the patient died.
- - The study concludes that early and accurate diagnosis of RCM is crucial due to its rapid progression, and mNGS can be particularly useful when traditional testing methods fail to identify the infection.
Article Abstract
Background: Mucormycosis is a rare opportunistic invasive fungal disease. Rhinocerebral mucormycosis (RCM) is clinically difficult to diagnose, and patients often die due to delayed diagnosis.
Case Description: A patient with concurrent pulmonary aspergillosis was diagnosed with RCM caused by through metagenomic Next-Generation Sequencing (mNGS). Despite comprehensive treatment including surgery, amphotericin B, and posaconazole, the patient tragically passed away. The treatment was delayed due to repeated cultures of secretions were negative and pathological examination could not clarify which fungus is infected.
Conclusion: The clinical manifestations of RCM are not specific in the early stage, but the infection progresses rapidly. Therefore, early and accurate diagnosis is very important. mNGS is helpful for patients suspected of RCM, especially when conventional microbiology tests were negative.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461224 | PMC |
| http://dx.doi.org/10.3389/fmed.2024.1398714 | DOI Listing |
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