AI Article Synopsis
- This study aimed to explore whether gastroesophageal reflux disease (GERD) causes hypertension using a two-sample Mendelian randomization analysis.
- Data was obtained from the genome-wide association study (GWAS) database, analyzing 16 specific genetic markers linked to GERD.
- The analysis indicated a significant causal relationship, showing that GERD is associated with an increased risk of hypertension, with no signs of bias in the results.
Article Abstract
Objective: The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis.
Methods: The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension.
Results: A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044-1.071; < 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032-1.07; < 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome.
Conclusion: There is a positive causal relationship between GERD and hypertension.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462550 | PMC |
| http://dx.doi.org/10.3389/fcvm.2024.1326348 | DOI Listing |
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