AI Article Synopsis
- - The study developed intestinal organoids from Wuzhishan miniature pigs (WZS pigs), providing a new model for researching intestinal health and disease.
- - Researchers created 3D organoids and monolayers, which were tested for their vulnerability to the transmissible gastroenteritis virus (TGEV).
- - RNA-seq analysis showed that TGEV infection triggered immune responses, highlighting potential risks of swine enteric coronavirus transmission in WZS pigs and supporting their use as laboratory models.
Article Abstract
Intestinal organoids are valuable tools for investigating intestinal physiology and pathology . In previous studies, intestinal organoids of commercial pigs have been developed. Here, we established intestinal organoids derived from Wuzhishan miniature pigs (WZS pigs), a unique kind of pig in the Hainan province of China. Three-dimensional (3D) intestinal organoids and organoid monolayers were developed and assessed. Furthermore, the susceptibility of organoid monolayers of WZS pigs to transmissible gastroenteritis virus (TGEV) was demonstrated. An RNA-seq analysis revealed that the TGEV infection stimulated antiviral and inflammatory immune responses in organoid monolayer models. The study implied the transmission risk of swine enteric coronavirus on WZS pigs and provided useful tools for further research on WZS pigs as laboratory miniature pig models.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461462 | PMC |
| http://dx.doi.org/10.3389/fvets.2024.1457719 | DOI Listing |
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