Background: mutation is one of the most common driver oncogenes in non-small cell lung cancer (NSCLC), and the most common mutation subtype is . However, there is still a lack of efficacy and prognosis data related to immunotherapy, which hinders the promotion of new strategies.
Methods: Clinical characteristics and treatment outcomes were collected and analyzed for patients with NSCLC harboring mutations at West China Hospital of Sichuan University from June 2013 to March 2023.
Results: Among the 231 patients with -mutated NSCLC, 29.4% had mutations. Compared to the NSCLC group, the NSCLC group had a greater number of pack-years. The programmed death ligand 1 expression and the proportion of patients with a high tumor mutational burden were not significantly different between the two groups. Similar patterns of , and mutations were observed between and NSCLC groups. The median progression-free survival (PFS) (8.4 vs 7.0 months, p=0.100) and overall survival (OS) (12.1 vs 18.1 months, p=0.590) were not statistically different between and . Compared to patients with NSCLC who did not receive immunotherapy, patients who received immunotherapy had a better objective response rate (46.2% vs 0%, p=0.002), PFS (12.2 vs 7.5 months, p=0.087) and OS (49.9 vs 11.1 months, p=0.12).
Conclusion: Patients with were more likely to be smokers. Advanced NSCLC patients who received immunotherapy had a better ORR than those who did not, suggesting that patients with mutations are more likely to benefit from immunotherapy.
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| http://dx.doi.org/10.2147/IJGM.S484435 | DOI Listing |
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