AI Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease, and this study explored how high levels of eosinophils in blood and tissue affect patient outcomes.
- Researchers divided 144 CRSwNP patients into four groups based on their eosinophil counts and found that those with high levels in both blood and tissue experienced more severe symptoms and complications.
- The study concluded that having eosinophils in blood or tissue leads to worse disease control post-surgery, highlighting the importance of monitoring eosinophil levels in CRSwNP patients.
Article Abstract
Purpose: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease with varied clinical features and treatment effects. This study aimed to investigate the additive effect of blood and tissue eosinophilia on patients with CRSwNP.
Methods: Based on the blood eosinophil (Beos) count and tissue eosinophil (Teos) count, we divided 144 CRSwNP patients into four groups, analysed their clinical features and histopathologic changes, and investigated their postoperative control.
Results: Patients in the BeosTeos (blood eosinophil count > 0.3 × 10/L, tissue eosinophil count > 10/HPF) group had a higher incidence of allergic rhinitis (AR) and asthma. Lund-Mackay (LM) scores, hyposmia visual analogue scale (VAS) scores and Global Osteitis Scoring Scale (GOSS) scores were higher in the BeosTeos group than those in the other groups. Tissue remodelling, such as connective tissue oedema and basement membrane thickening was more severe in the BeosTeos group compared with other groups. There were more uncontrolled patients after surgery in BeosTeos, BeosTeos (blood eosinophil count > 0.3 × 10/L, tissue eosinophil count ≤ 10/HPF)and BeosTeos (blood eosinophil count ≤ 0.3 × 10/L, tissue eosinophil count > 10/HPF)groups compared with the BeosTeos group.
Conclusions: Eosinophilic inflammation both in blood and tissue was accompanied by more severe clinical features and tissue remodelling. Eosinophilia in blood or tissue indicated poorer disease control after surgery.
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| http://dx.doi.org/10.1111/coa.14243 | DOI Listing |
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