AI Article Synopsis
- The study focuses on head and neck squamous cell carcinoma (HNSCC) and its metastasis, analyzing data from 702,446 cells to find a new subtype of cancer-associated fibroblasts (CAFs) called SFRP2_CAFs.
- SFRP2_CAFs, derived from smooth muscle cells, show distinct traits that relate to worse survival in HNSCC patients and exhibit interactions with tumor-associated macrophages that promote tumor spread.
- The research highlights NFIX as a crucial transcription factor that influences the behavior of SFRP2_CAFs, using advanced gene regulatory network analysis for validation.
Article Abstract
Understanding the mechanisms of invasion and metastasis in head and neck squamous cell carcinoma (HNSCC) is crucial for effective treatment, particularly in metastatic cases. In this study, we analyzed multicenter bulk sequencing and comprehensive single-cell data from 702,446 cells, leading to the identification of a novel subtype of cancer-associated fibroblasts (CAFs), termed Secreted Frizzled-Related Protein2 CAFs (SFRP2_CAFs). These cells, originating from smooth muscle cells, display unique characteristics resembling both myofibroblastic CAFs and inflammatory CAFs, and are linked to poorer survival outcomes in HNSCC patients. Our findings reveal significant interactions between SFRP2_CAFs and SPP1 tumor-associated macrophages, which facilitate tumor invasion and metastasis. Moreover, our research identifies Nuclear factor I/X (NFIX) as a key transcription factor regulating SFRP2_CAFs behavior, confirmed through gene regulatory network analysis and simulation perturbation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464629 | PMC |
| http://dx.doi.org/10.1038/s41698-024-00716-5 | DOI Listing |
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