Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vaa.2024.09.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reduction of postoperative pain and opioid consumption by VVZ-149, first-in-class analgesic molecule: A confirmatory phase 3 trial of laparoscopic colectomy.
J Clin Anesth
December 2024
Department of Anesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:
Study Objective: VVZ-149 is a small molecule that inhibits the glycine transporter type 2 and the serotonin receptor 5-hydroxytryptamine 2 A. In this Phase 3 study, we investigated the efficacy and safety of VVZ-149 as a single-use injectable analgesic for treating moderate to severe postoperative pain after laparoscopic colectomy.
Design: Randomized, parallel group, double-blind, Phase 3 clinical trial (Trial no.
Analgesia After Vestibular Schwannoma Surgery in Europe-Potential for Reduction of Postoperative Opioid Usage.
Otol Neurotol
January 2025
Department of Neurosurgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Objective: Excessively prescribed opioids promote chronic drug abuse and worsen a highly prevalent public health problem in the era of the opioid epidemic. This study aimed to (a) determine general analgesic prescription patterns after surgery for vestibular schwannoma (VS) with a focus on opioid prescription rates, (b) identify risk factors for receiving narcotics for postoperative pain management, and (c) highlight the feasibility of opioid-free analgesic treatment strategies.
Study Design: Retrospective chart review.
Risk Factors for Cervical Hematoma After Thyroid Surgery at a Portuguese Hospital: A Retrospective Study.
Cureus
November 2024
Anesthesiology, Unidade Local de Saúde (ULS) de Viseu Dão-Lafões, Viseu, PRT.
Objective: Cervical hematoma post thyroid surgery is an uncommon but potentially life-threatening postoperative complication. Moreover, despite its low incidence, this complication has been a barrier to outpatient surgical care. Assessing postoperative complication rates and their risk factors can improve the safety and cost-effectiveness of these procedures, which is especially useful in promoting outpatient surgical care.
View Article and Find Full Text PDFEffect of Opioid-Free General Anesthesia Versus Opioid-Based General Anesthesia on Postoperative Pain and Immune Response in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Trial.
Indian J Surg Oncol
December 2024
Department of Onco-Anesthesia and Palliative Medicine, AIIMS, Dr BRAIRCH, New Delhi, India.
Article Synopsis
- Opioid-free anesthesia may reduce adverse effects like addiction and nausea common with opioids, and could improve outcomes for patients undergoing breast cancer surgery.
- In a study with 100 patients, two groups were formed: one receiving opioid-based anesthesia and the other receiving none, with outcomes measured like pain scores and morphine use post-surgery.
- Results showed no significant difference in morphine consumption or patient satisfaction between the two groups, but the opioid-free group had a notable difference in an immune marker, suggesting that this method is safe and might help patients sensitive to opioids.
Non-Opioid Analgesia Protocols After Total Hip Arthroplasty and Total Knee Arthroplasty: An Updated Scoping Review and Meta-Analysis.
J Arthroplasty
November 2024
Division of Arthroplasty, Department of Orthopedic Surgery, New England Baptist Hospital, Boston, Massachusetts.
Background: Despite their effectiveness in postoperative analgesia regimens for total knee arthroplasty (TKA) and total hip arthroplasty (THA), opioid medications are accompanied by well-known side effects and a risk of long-term dependence. These drawbacks have prompted the exploration of opioid-free analgesia protocols. The purpose of this study was to summarize the nature and extent of evidence available on opioid-free analgesia protocols in THA and TKA management.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!