AI Article Synopsis
- The objective of the study was to characterize primary extranodal non-Hodgkin lymphomas in the head and neck and assess patient survival and prognostic factors over a period from 2005 to 2016.
- A total of 145 patients were analyzed, with 69.3% having localized disease and 91.8% being of B-cell phenotype, predominantly diffuse large B-cell lymphoma; most were treated with immunochemotherapy.
- Survival rates at 3 and 5 years were 75% and 73%, with adverse prognostic indicators including low hemoglobin, high ß2-microglobulin, high LDH levels, advanced disease stages, and presence of B symptoms at diagnosis.*
Article Abstract
Objective: To make a clinical-biological characterization of this pathology and assess the survival of these patients and the associated prognostic factors.
Study Design: A retrospective observational study was designed to identify primary extranodal non-Hodgkin lymphomas of the head and neck diagnosed between January 1, 2005, and January 1, 2016. Cases were considered if they presented with a single tumor in situ or if the extranodal component was clinically predominant.
Results: A total of 145 patients were included. Localized stages (I-II) were present in 69.3%. Overall, 91.8% were B-cell phenotype, with diffuse large B-cell lymphoma being the most frequent. Overall, 78% of patients were treated with immunochemotherapy. The overall survival at 3 and 5 years was 75% and 73%, respectively. Adverse prognostic factors were: low hemoglobin, elevated ß2-microglobulin, and lactate dehydrogenase (LDH) levels, Eastern Cooperative Oncology Group (ECOG), stage III/IV, and B symptomatology at diagnosis. The progression-free survival at 3 and 5 years was 71% and 68%. Risk factors for relapse were high ß2-microglobulin, high LDH, and stage III-IV at diagnosis.
Conclusions: These pathologies show a good response to treatment with immuno-polychemotherapy. Factors associated with a worse prognosis included low hemoglobin, elevated levels of ß2-microglobulin and LDH, elevated ECOG, stage III/IV, and B symptomatology at diagnosis.
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| http://dx.doi.org/10.1016/j.oooo.2024.09.007 | DOI Listing |
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