AI Article Synopsis
- Keratinocytes are negatively affected by airborne particulate matter (PM), leading to skin barrier issues and inflammation.
- The study investigated the effects of 7S MaR1, a compound derived from fatty acids, on skin inflammation and oxidative stress caused by PM10 in human skin cells.
- Results showed that 7S MaR1 helps reduce harmful ROS (reactive oxygen species) and inflammatory markers, suggesting its potential role in alleviating skin damage from particulate matter exposure.
Article Abstract
Keratinocytes are susceptible to airborne particulate matter (PM) exposure, resulting in human skin barrier dysfunction. Therefore, it is important to find useful reagents to resolve skin damages caused by PM. Here, we explored the protective effect of 7S MaR1, a specialized pro-resolving mediator derived from docosahexaenoic acid, on skin inflammation and the oxidative stress induced by PM with a diameter 10 μm or less (PM10) in human keratinocyte HaCaT cells. Interestingly, PM10-induced ROS generation was modulated by 7S MaR1 via the recovery of ROS scavenger genes. 7S MaR1 reduced PM10-induced IL-6 expression via modulating the p38/ERK/NF-κB signaling pathways. These results demonstrate that PM induces inflammatory cytokines, which can lead to skin diseases. In addition, 7S MaR1 can resolve inflammation caused by PM-induced oxidative stress and inflammatory cytokines. [BMB Reports 2024; 57(11): 490-496].
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608853 | PMC |
| http://dx.doi.org/10.5483/BMBRep.2024-0124 | DOI Listing |
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