AI Article Synopsis
- The immune system typically responds to harmless substances from food and gut bacteria by activating regulatory responses instead of inflammation, which is crucial for maintaining balance.
- Antigen-presenting cells (APCs) play a key role in influencing T cell behavior; if APCs don't function properly, it can lead to immune issues like inflammation and imbalances in gut bacteria.
- The review highlights the importance of different APC types in guiding T cell responses to dietary and microbial antigens, opening up possibilities for research into how these interactions can affect immune-related conditions like allergies and inflammation.
Article Abstract
The immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate, non-inflammatory responses. This process requires antigen-presenting cells (APCs) that induce T cells with either regulatory or effector functions. Compromised APC function disrupts the T cell balance, leading to inflammation and dysbiosis. Although their precise identities continue to be debated, it has become clear that multiple APC lineages direct the differentiation of distinct microbiota-specific CD4 T cell programs. Here, we review how unique APC subsets instruct T cell differentiation and function in response to microbiota and dietary antigens. These discoveries provide new opportunities to investigate T cell-APC regulatory networks controlling immune homeostasis and perturbations associated with inflammatory and allergic diseases.
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| http://dx.doi.org/10.1016/j.immuni.2024.09.011 | DOI Listing |
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