AI Article Synopsis
- - The study focuses on identifying factors that enhance the effectiveness of adoptive cell therapies using tumor-infiltrating lymphocytes (TIL-ACT) to optimize treatment methods.
- - Chiffelle et al. conduct an in-depth comparison of CD8 T cell clonotypes, examining their behavior in patients who respond well to the therapy versus those who do not.
- - Insights from this research aim to improve understanding of TIL-ACT responses, potentially leading to better therapeutic strategies for cancer treatment.
Article Abstract
Understanding the factors that lead to the therapeutic success of adoptive cell therapies using tumor-infiltrating lymphocytes (TIL-ACT) will improve current treatment protocols. In this issue of Immunity, Chiffelle et al. comprehensively compare the dynamics of CD8 T cell clonotypes during the course of ACT between responding and non-responding patients.
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| http://dx.doi.org/10.1016/j.immuni.2024.09.012 | DOI Listing |
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