AI Article Synopsis
- Antibodies are important for antiviral responses across many species, but bats were previously thought to have weak humoral immunity.
- Recent research shows that Jamaican fruit bats can generate a strong and stable immune response, including effective neutralizing antibodies, when infected with the bat influenza A virus H18N11.
- This immune response is linked to the absence of viral shedding after multiple infections, suggesting that neutralizing antibodies may significantly contribute to bat immunity.
Article Abstract
Antibodies are an essential component of the antiviral response in many species, but to date, there is no compelling evidence that bats are capable of eliciting a robust humoral immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494324 | PMC |
| http://dx.doi.org/10.1073/pnas.2413619121 | DOI Listing |
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