AI Article Synopsis
- The study investigates the role of anti-PSMA1 antibodies in idiopathic nephrotic syndrome (INS) among children, aiming to understand its effects on podocyte function.
- Researchers found that levels of these antibodies were higher in INS patients and correlated with urinary protein levels, indicating an association with disease severity.
- Experiments in mice and zebrafish demonstrated that PSMA1 is crucial for maintaining podocyte structure and function, with deficiencies leading to significant kidney damage and morphological changes.
Article Abstract
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| http://dx.doi.org/10.1681/ASN.0000000525 | DOI Listing |
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