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The role of sonic hedgehog signaling in the oropharyngeal epithelium during jaw development.
Congenit Anom (Kyoto)
December 2024
Department of Molecular Craniofacial Embryology and Oral Histology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Sonic hedgehog (Shh) is expressed in the oropharyngeal epithelium, including the frontonasal ectodermal zone (FEZ), which is defined as the boundary between Shh and Fgf8 expression domains in the frontonasal epithelium. To investigate the role of SHH signaling from the oropharyngeal epithelium, we generated mice in which Shh expression is specifically deleted in the oropharyngeal epithelium (Isl1-Cre; Shh). In the mutant mouse, Shh expression was excised in the oropharyngeal epithelium as well as FEZ and ventral forebrain, consistent with the expression pattern of Isl1.
View Article and Find Full Text PDFMoving Beyond the Bladder Diary: Does New Technology Now Allow Us to Take Investigation of LUTS Into the Community? ICI-RS 2024.
Neurourol Urodyn
December 2024
Department of Physical Medicine and Rehabilitation, Rothschild Hospital, Sorbonne Université, Paris, France.
Context: Lower Urinary Tract Symptoms (LUTS) are defined by their distressing effect on patients' day-to-day life. Given the pressures on secondary care resources, LUTS may be overlooked or inadequately assessed and therefore patients may be burdened for an extended period before treatment.
Methods: In a debate held at the International Consultation on Incontinence Research Society (ICI-RS) meeting in Bristol in June 2024, we considered how new technologies might contribute to an expedited, dignified and effective investigation of LUTS.
Recent advances in understanding pathophysiology of nonnutritional stunting in very preterm infants.
Clin Exp Pediatr
December 2024
Department of Pediatrics and Neonatology, Hospital Privado Universitario de Córdoba., Córdoba., Argentina.
Very preterm infants (VPIs) often experience extrauterine growth failure. Therefore, aggressive nutritional management of VPIs is recommended with the goal of achieving the postnatal growth of an equivalent fetus. However, VPIs frequently present postnatal length growth restriction at term-corrected age that remains lower than the standard weight and have greater fat mass and lower lean and bone mass than term-born infants.
View Article and Find Full Text PDFIntegrating food is medicine and regenerative agriculture for planetary health.
Front Nutr
December 2024
Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States.
The urgent need to address both human and environmental health crises has brought attention to the role of food systems in driving climate change, biodiversity loss, and diet-related diseases. This paper explores the intersection of Food is Medicine (FIM) and regenerative agriculture (RA) as an emerging approach with the potential to help address the interconnected challenges of human and ecological health within healthcare and food systems. FIM programs, such as produce prescriptions and medically tailored meals, aim to improve health outcomes by increasing access to nutritious foods and promoting nutrition equity.
View Article and Find Full Text PDFPrognostic role of bone erosion in orbital RMS: a report from the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG).
Front Oncol
December 2024
Department of Women's and Children's Health, University of Padova, Padova, Italy.
Background: Orbital rhabdomyosarcoma (RMS) is often limited to the orbital cavity and has a favorable prognosis. In some cases, the tumor can erode the orbital bone and behave as a parameningeal RMS (PM-RMS); thus, it is treated more intensively. However, the current protocols do not provide any guidance on how to consider different grades of bone erosion (BE) that can vary widely, hampering a uniform classification and the subsequent treatment assignment.
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