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Ventral Hernia Repair With a Hybrid Absorbable-permanent Preperitoneal Mesh. | LitMetric

AI Article Synopsis

  • - The study focused on evaluating the safety and effectiveness of the GORE SYNECOR Preperitoneal Biomaterial (PRE device) for ventral hernia repairs, involving a retrospective review of outcomes for 148 patients over more than a year post-surgery.
  • - Results showed a low incidence of adverse events within 30 days (8.8% overall), with the main complications being surgical site infections (4.8%) and the need for reoperations (2.0%). Importantly, no hernia recurrences were reported during the study.
  • - The findings suggest that the PRE device is both safe and effective for complex repairs, combining the benefits of absorbable and permanent mesh materials when placed in the retromuscular

Article Abstract

Objective: To analyze device safety and clinical outcomes of ventral hernia repair with the GORE SYNECOR Preperitoneal Biomaterial (PRE device), a permanent high-strength mesh with bioabsorbable web scaffold technology.

Materials And Methods: This multicenter retrospective review analyzed device/procedure endpoints and patient-reported outcomes in patients treated for hernia repair ≥1 year from study enrollment.

Results: Included in this analysis were 148 patients with a mean age of 56 years; 66.2% met the Ventral Hernia Working Group grade 2 classification. Median hernia size was 30.0 cm 2 and 58.8% of patients had an incisional hernia. Repairs were primarily a robotic (53.4%) or open approach (41.9%). All meshes were placed extraperitoneal. Procedure-related adverse events within 30 days occurred in 13 (8.8%) patients and included 7 (4.8%) patients with surgical site infection, 2 (1.4%) with surgical site occurrence (SSO), 4 (2.7%) requiring readmission, and 3 (2.0%) who had reoperation. The rate of SSO events requiring procedural intervention was 2.7% (4 patients) through 30 days and 3.4% (5 patients) at 12 months. The rate of procedure-related surgical site infection remained at 4.8% through 12 months (no further reports after 30 d) and 3.4% for SSO (2 reports after 30 d). There were no site-reported clinically diagnosed hernia recurrences throughout the study. Median patient follow-up including in-person visit, physical examination, reported adverse event, explant, death, and questionnaire response was 28 months (n = 148). Median patient follow-up with patient questionnaire was 36 months (n = 88).

Conclusions: Use of the PRE device, which incorporates the proven advantages of both an absorbable synthetic mesh and the long-term durability of a permanent macroporous mesh, is safe and effective in complex ventral hernia repairs. When used in the retromuscular space, the combination of these 2 materials had lower wound complications and recurrence rates than either type of material alone.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614456PMC
http://dx.doi.org/10.1097/SLE.0000000000001327DOI Listing

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