Enhancing radiotherapy for melanoma: the promise of high-Z metal nanoparticles in radiosensitization.

Nanomedicine (Lond)

Center for Global health Research, Saveetha Medical College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, India.

Published: October 2024

AI Article Synopsis

  • * Recent studies are exploring the use of high-Z metal nanoparticles (NPs) to boost the effectiveness of radiotherapy for melanoma by enhancing the cancer cells' sensitivity to radiation.
  • * This review highlights the current advancements in radiotherapy for melanoma, focusing on the mechanisms by which high-Z metal NPs can improve treatment outcomes for patients.

Article Abstract

Melanoma is a type of skin cancer that can be challenging to treat, especially in advanced stages. Radiotherapy is one of the main treatment modalities for melanoma, but its efficacy can be limited due to the radioresistance of melanoma cells. Recently, there has been growing interest in using high-Z metal nanoparticles (NPs) to enhance the effectiveness of radiotherapy for melanoma. This review provides an overview of the current state of radiotherapy for melanoma and discusses the physical and biological mechanisms of radiosensitization through high-Z metal NPs. Additionally, it summarizes the latest research on using high-Z metal NPs to sensitize melanoma cells to radiation, both and . By examining the available evidence, this review aims to shed light on the potential of high-Z metal NPs in improving radiotherapy outcomes for patients with melanoma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492696PMC
http://dx.doi.org/10.1080/17435889.2024.2403325DOI Listing

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