Melanoma is a type of skin cancer that can be challenging to treat, especially in advanced stages. Radiotherapy is one of the main treatment modalities for melanoma, but its efficacy can be limited due to the radioresistance of melanoma cells. Recently, there has been growing interest in using high-Z metal nanoparticles (NPs) to enhance the effectiveness of radiotherapy for melanoma. This review provides an overview of the current state of radiotherapy for melanoma and discusses the physical and biological mechanisms of radiosensitization through high-Z metal NPs. Additionally, it summarizes the latest research on using high-Z metal NPs to sensitize melanoma cells to radiation, both and . By examining the available evidence, this review aims to shed light on the potential of high-Z metal NPs in improving radiotherapy outcomes for patients with melanoma.
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http://dx.doi.org/10.1080/17435889.2024.2403325 | DOI Listing |
ACS Nano
December 2024
Guangzhou Key Laboratory of Tumor Immunology Research, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P.R. China.
Ferroptosis plays an important role in radiotherapy (RT), and the induction of ferroptosis can effectively sensitize radiotherapy. However, the therapeutic efficiency is always affected by ferroptosis resistance, especially SLC7A11 (Solute Carrier Family 7 Member 11)-cystine-cysteine-GSH (glutathione)-GPX4 (glutathione peroxidase 4) pathway-mediated resistance. In this study, tumor-microenvironment self-activated high-Z element-containing nanoferroptosis inducers, PEGylated Fe-Bi-SS metal-organic frameworks (FBSP MOFs), were developed to sensitize RT.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.
Hydroalkylation of terminal alkynes is a powerful approach to the synthesis of disubstituted alkenes. However, its application is largely unexplored in the synthesis of α,β-unsaturated carbonyls, which are common among synthetic intermediates and biologically active molecules. The thermodynamically less stable -isomers of activated alkenes have been particularly challenging to access because of their propensity for isomerization and the paucity of reliable -selective hydroalkylation methods.
View Article and Find Full Text PDFBiomed Phys Eng Express
December 2024
Department of Radiation Oncology, Northwest Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, United States of America.
. Electron beam treatment often requires bolus to augment surface dose to nearly 100%. There are no optimum bolus materials and hence a high-Z based clothlike material is investigated to reduce air column in treatment that provides optimum surface dose.
View Article and Find Full Text PDFPhys Med Biol
December 2024
Centre Hospitalier Universitaire (CHU) de Québec - Université Laval 2705, 2705, boul. Laurier (T1-61a) - CR-CHU-CHUL, Québec (Québec), Canada,, Québec, Québec, Quebec, G1V 4G2, CANADA.
Objective: Biodegradable cardiovascular stents made of thin, low atomic number metals (e.g. Zn, Mg, Fe) are now approved for clinical use.
View Article and Find Full Text PDFACS Nano
December 2024
Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Preclinical and clinical diagnostics depend greatly on medical imaging, which enables the identification of physiological and pathological processes in living subjects. It is often necessary to use contrast agents to complement anatomical data with functional information or to describe the disease phenotypically. Nanomaterials are used as contrast agents in many advanced bioimaging techniques and applications because of their high payload, physicochemical properties, improved sensitivity, and multimodality.
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