AI Article Synopsis
- Sepsis is a major health issue in newborns, and researchers studied the effectiveness of the sTREM-1 biomarker for identifying early onset neonatal sepsis (EONS) in 52 suspected cases compared to 30 healthy newborns.
- They found that while certain other biomarkers (like CRP and neutrophil levels) were significantly elevated in EONS cases, sTREM-1 levels did not show a meaningful difference between EONS patients and healthy newborns.
- The study concluded that more extensive research with larger groups and repeated measurements is needed to determine the real value of sTREM-1 in clinical practice for diagnosing neonatal sepsis.
Article Abstract
Sepsis remains a significant cause of morbidity and mortality in neonates. We aimed to investigate the use and reliability of the soluble triggering receptor expressed on myeloid cells (sTREM-1) biomarker for suspected early onset of neonatal sepsis (EONS). 52 patients with suspected EONS and 30 healthy newborns were analyzed for sTREM-1 and other biomarkers. It revealed that elevated levels of C-reactive protein (CRP), neutrophil (%), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR) and lactate, as well as decreased lymphocyte (%) were statistically significant for EONS. However, there was no statistically significant difference in sTREM-1 levels between the groups. Although no significant difference in sTREM-1 levels was found between the groups, further research involving repeated measurements and larger sample sizes is necessary to evaluate its practical utility in clinical settings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492702 | PMC |
| http://dx.doi.org/10.1080/17460913.2024.2406654 | DOI Listing |
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