AI Article Synopsis
- The sea cucumber is a vital species in Chinese aquaculture, but the mechanisms behind its sex determination are not well understood.
- This study analyzed sex-related genetic variations in several wild populations, indicating that sea cucumbers use a polygenic sex determination system with the SLC8A gene as a candidate for determining sex.
- Researchers identified specific male-related genetic markers and significant chromosomal variations, suggesting a complex, multi-gene approach to sex determination rather than the typical XX/XY model.
Article Abstract
The sea cucumber , a key species in Chinese aquaculture, plays a significant evolutionary role within the Echinodermata phylum. However, the sex determination mechanism in this species remains poorly understood. Here, we conducted extensive sex surveys and sampling of eight wild populations, investigating the sex-related SNPs and insertion or deletions (indels) through bulk segregation analysis (BSA) and genome-wide association study (GWAS) analysis. Our findings suggest that employs a polygenic sex determination (PSD) system, with solute carrier family 8 (SLC8A) being the candidate gene for sex determination, encoding sodium-calcium exchanger (NCX1). The analysis of normalized sequencing depth reveals variations across chromosomes 6, 13, 14, 16, and 18, supporting the PSD system. We also identified 541.656 kb of male-specific sequences and screened five markers (C77185, C98086, C64977, C125, and C876) for molecular sex identification. Overall, this study provides new insights into sex determination, highlighting a complex multi-gene mechanism rather than a simple XX/XY system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458978 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110852 | DOI Listing |
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