AI Article Synopsis
- SLITs are proteins that act as ligands for ROBO receptors, which are important for cell signaling.
- Research indicates that ROBO1 helps mammary cells differentiate and produce milk by blocking Notch signaling.
- In experiments, knockout mice lacking SLIT2 and SLIT3 showed better development of milk-producing cells and higher milk production, suggesting that SLITs inhibit this process by interfering with ROBO1.
Article Abstract
SLITs comprise a family of secreted proteins that function as ligands for Roundabout (ROBO) receptors. Previous research showed that ROBO1 promotes the differentiation of milk-producing alveolar cells by inhibiting Notch signaling in mammary luminal cells. Here, we show enhanced alveolar development and increased milk production in Slit2-/-;Slit3-/- knockout mammary gland epithelia. This result can also be achieved by intraperitoneal delivery of recombinant ROBO1 extracellular domain fragment, ROBO1-5Ig-Fc, which sequesters SLITs. Together, our phenotypic studies suggest that SLITs restrict alveologenesis and lactogenesis by inhibiting ROBO1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461027 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001264 | DOI Listing |
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