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| http://dx.doi.org/10.13107/jocr.2024.v14.i10.4788 | DOI Listing |
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Efficient and generalizable prediction of molecular alterations in multiple cancer cohorts using H&E whole slide images.
Mod Pathol
December 2024
Tempus AI, Inc, Chicago, IL. Electronic address:
Molecular testing of tumor samples for targetable biomarkers is restricted by a lack of standardization, turnaround-time, cost, and tissue availability across cancer types. Additionally, targetable alterations of low prevalence may not be tested in routine workflows. Algorithms that predict DNA alterations from routinely generated hematoxylin and eosin (H&E)-stained images could prioritize samples for confirmatory molecular testing.
View Article and Find Full Text PDFEvaluation of Exosomal Proteins as Potential Biomarkers from RBC Stages of 3D7.
ACS Infect Dis
December 2024
Department of Zoology, BMTC, Human Genetics and Wildlife Biology and Conservation, School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India.
Falciparum malaria relies extensively on cell-to-cell communication, and earlier research on the function of exosomal proteins derived from infected red blood cells (iRBCs) has been classified into numerous important roles. In this study, the exosomes were derived from -iRBCs cultured in vitro during synchronized trophozoite stages. The isolated exosomes were assessed using NTA, FE-SEM, and flow cytometry.
View Article and Find Full Text PDFVisible Light Triggerable CO Releasing Micelles.
J Am Chem Soc
December 2024
Department of Chemistry & Biochemistry, University of Denver, Denver, Colorado 80210, United States.
Carbon monoxide (CO), along with nitric oxide and hydrogen sulfide, is one of a trinity of known gasotransmitters, or endogenously produced gaseous molecules that signal and regulate a panoply of physiological functions. CO releasing molecules (CORMs) are chemical tools that enable the study and application of this ephemeral gas, that, ideally, release CO on-demand when externally stimulated. Surveying the available triggers, photolysis is potentially advantageous: It is contactless and grants practitioners unparalleled spatial and temporal control.
View Article and Find Full Text PDFManagement of bulbar strictures in boys following previous endoscopic treatment of posterior urethral valves.
J Pediatr Urol
November 2024
UROKUL, Kulkarni Reconstructive Urology Centre, Pune, India.
Introduction: Urethral strictures following endoscopic management of Posterior Urethral Valves (PUV) varies from 0 % to 25 % and occurs due to iatrogenic injury of the urethra.
Objectives: To assess the outcomes of children undergoing urethral reconstruction following an iatrogenic injury during endoscopic management of PUV.
Methods: A retrospective review of a prospectively maintained database from 2015 to 2023 was undertaken of children who were referred following an iatrogenic injury to the urethra from prior endoscopic management of PUV.
Comparison of Recovery Rate of Otomycosis using One-Percent Gentian Violet and One-Percent Clotrimazole Topical Treatment.
J Nepal Health Res Counc
October 2024
Department of ENT-HNS, National Academy of Medical Sciences, Kathmandu, Nepal.
Background: Otomycosis is a fungal infection of external auditory canal with worldwide prevalence of 9% to 30%. Treatment includes elimination of predisposing factor, thorough canal cleaning and topical or systemic antifungal agents. Clotrimazole is a specific topical antifungal agent with effectiveness varying from 95% to 100%.
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