The liver, the largest gland in a wedge-shape, is situated in the right hypochondrium, and exhibits variation in its lobes. Knowledge of variations in the lobes of the liver is crucial for accurate radiological diagnosis and successful abdominal surgeries. The elongation of the left lobe of the liver has gained significant attention in segmentectomy and liver transplant surgeries. During October and November 2023, cross-sectional observational research was done on 53 human cadaveric liver specimens obtained from different medical colleges in Gujarat, India. The livers were meticulously examined to determine the prevalence of Beaver tail liver and measurements such as length, breadth, and thickness were recorded and statistically analyzed. The study revealed that out of the 53 livers examined, 29 (54.72%) were classified as normal, while 19 (35.85%) fell into Netter's type 2 to 7 based on Netter's classification. Interestingly, 5 (09.43%) livers exhibited an elongated left lobe, referred to as a "sliver liver," which did not fit into any of the Netter's types. The beaver tail liver was found to be longer and broader compared to normal liver of the same size and weight (p<0.001). This study highlights the wide range of variations that can be observed in the lobes of the liver. The findings of this study will serve as a valuable resource for radiologists, anatomists, and surgeons, aiding them in accurate diagnoses and surgical procedures, thus minimizing the risk of misdiagnosis.
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http://dx.doi.org/10.4068/cmj.2024.60.3.187 | DOI Listing |
FASEB J
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Microgravity-induced cardiac remodeling and dysfunction present significant challenges to long-term spaceflight, highlighting the urgent need to elucidate the underlying molecular mechanisms and develop precise countermeasures. Previous studies have outlined the important role of miRNAs in cardiovascular disease progression, with miR-199a-3p playing a crucial role in myocardial injury repair and the maintenance of cardiac function. However, the specific role and expression pattern of miR-199a-3p in microgravity-induced cardiac remodeling remain unclear.
View Article and Find Full Text PDFPLoS Genet
January 2025
Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1st St. SW, Rochester, Minnesota 55905, United States of America.
Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and progressive bulbar palsy, involve loss of muscle control resulting from death of motor neurons. Although the exact pathogenesis of these syndromes remains elusive, many are caused by genetically inherited mutations. Thus, it is valuable to identify additional genes that can impact motor neuron survival and function.
View Article and Find Full Text PDFThe antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T. versicolor-ePSP on regulating glucose metabolism, including insulin signaling molecules and glucose metabolism-associated enzymes, in the liver of rats with type 2 diabetes mellitus (T2DM).
View Article and Find Full Text PDFElife
January 2025
Department of Mechanical Engineering, University of Rochester, Rochester, United States.
We hypothesized that active outer hair cells drive cochlear fluid circulation. The hypothesis was tested by delivering the neurotoxin, kainic acid, to the intact round window of young gerbil cochleae while monitoring auditory responses in the cochlear nucleus. Sounds presented at a modest level significantly expedited kainic acid delivery.
View Article and Find Full Text PDFJ Clin Invest
January 2025
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Stimulator of interferon genes (STING) agonists have been developed and tested in clinical trials for their antitumor activity. However, the specific cell population(s) responsible for such STING activation-induced antitumor immunity have not been completely understood. In this study, we demonstrated that endothelial STING expression was critical for STING agonist-induced antitumor activity.
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