AI Article Synopsis
- Coxsackievirus A16 (CV-A16) is a key cause of Hand, Foot and Mouth disease, and this study analyzed 287 genome sequences from 1994 to 2019 to explore its evolution.
- The research identified five genotypes (G-a to G-e) of CV-A16, with strains in China primarily falling under G-a and G-c, while also circulating in other genotypes.
- Findings revealed that genomic recombination has significantly influenced CV-A16's evolution, although its structural proteins have remained relatively stable over time.
Article Abstract
Coxsackievirus A16 (CV-A16) is one of the major pathogens of Hand, Foot and Mouth disease. Here, we analyzed 287 full-length genome sequences of CV-A16 found worldwide from 1994 to 2019 to see the genomic evolution characteristics. Full-length genome-based phylogenetic tree divided the viruses into five different genotypes, G-a to G-e. The CV-A16 strains circulating in China dominate G-a and G-c, but can also be found in other genotypes including G-b and G-e. Phylogeographic analysis showed a high diversity of CV-A16 distribution. In addition, recombination was shown to drive the genomic evolution of CV-A16 during past decades. However, the structural proteins still remain relative conserved while there is extensive genomic recombination. This study updates the phylogenetic and phylogeographic information of CV-A16 and provides insights into the genetic characteristics of CV-A16.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456955 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e38248 | DOI Listing |
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